Markin Kirill, Trufanov Artem, Tarumov Dmitriy, Krasichkov Alexander, Shichkina Yulia, Kupriyanov Mikhail
Psychiatry Department, Military Medical Academy, Saint Petersburg, Russia.
Department of Neurology and Manual Medicine of the Faculty of Postgraduate Education, Pavlov First Saint Petersburg State Medical University, Saint Petersburg, Russia.
Depress Anxiety. 2025 May 10;2025:5974860. doi: 10.1155/da/5974860. eCollection 2025.
This study aimed to identify temperament traits alterations in bipolar disorder (BD) and explore their potential neuroimaging correlates using resting-state functional magnetic resonance imaging. We assessed seed-to-voxel alterations in four large-scale brain networks (Salience, Frontoparietal, Default Mode, and SensoriMotor) in 49 patients with BD and 49 healthy individuals according to the difference of temperamental traits (Reward Dependence, Novelty Seeking, Harm Avoidance, and Persistence). Also, we measured the relationship of temperamental traits with the severity of manic and depressive symptoms and impulsivity. Lower Reward Dependence (t-Welch's (87.1) = -2.50; =0.014) in bipolar patients was associated with increased functional connectivity between Salience Network and Default Mode and FrontoParietal Networks. Higher Novelty Seeking (t-Welch's (87.3) = 4.37; < 0.001) was associated with increased functional connectivity within FrontoParietal Network, whereas its functional connectivity with Visual and Dorsal Attention Networks was decreased. Higher Harm Avoidance (t-Welch's (82.8) = 4.85; < 0.001) was associated with increased functional connectivity between FrontoParietal Network and basal ganglia. Lower Persistence ( = 998; =0.002) was associated with decreased functional connectivity within FrontoParietal Network and with Default Mode Network. Higher persistence in bipolar patients was associated with greater severity of manic symptoms (Spearman's rho = 0.302, =0.018), while lower Reward Dependence was associated with increased severity of depressive symptoms (Pearson's = -0.388, =0.003). Harm Avoidance negatively correlates with Persistence (Pearson's = -0.525, < 0.001) and positively with reward dependence (Pearson's = -0.259, =0.036). We also found a negative correlation between impulsivity and Reward Dependence (Pearson's = -0.312, =0.029) and positive correlation between impulsivity and Novelty Seeking (Pearson's = 0.525, < 0.001). The findings demonstrate a possible functional neuroimaging basis for altered temperamental traits in patients with bipolar disorder.
本研究旨在识别双相情感障碍（BD）患者气质特质的改变，并使用静息态功能磁共振成像探索其潜在的神经影像学关联。我们根据气质特质（奖赏依赖、新奇寻求、回避伤害和坚持性）的差异，评估了49例双相情感障碍患者和49名健康个体在四个大规模脑网络（突显网络、额顶叶网络、默认模式网络和感觉运动网络）中的种子点到体素的改变。此外，我们测量了气质特质与躁狂和抑郁症状严重程度以及冲动性之间的关系。双相情感障碍患者较低的奖赏依赖（t-韦尔奇检验（87.1）=-2.50；P=0.014）与突显网络和默认模式网络以及额顶叶网络之间功能连接性增加有关。较高的新奇寻求（t-韦尔奇检验（87.3）=4.37；P<0.001）与额顶叶网络内功能连接性增加有关，而其与视觉和背侧注意网络的功能连接性降低。较高的回避伤害（t-韦尔奇检验（82.8）=4.85；P<0.001）与额顶叶网络和基底神经节之间功能连接性增加有关。较低的坚持性（P=998；P=0.002）与额顶叶网络内以及与默认模式网络的功能连接性降低有关。双相情感障碍患者较高的坚持性与躁狂症状更严重相关（斯皮尔曼相关系数rho=0.302，P=0.018），而较低的奖赏依赖与抑郁症状严重程度增加相关（皮尔逊相关系数r=-0.388，P=0.003）。回避伤害与坚持性呈负相关（皮尔逊相关系数r=-0.525，P<0.001），与奖赏依赖呈正相关（皮尔逊相关系数r=-0.259，P=0.036）。我们还发现冲动性与奖赏依赖呈负相关（皮尔逊相关系数r=-0.312，P=0.029），与新奇寻求呈正相关（皮尔逊相关系数r=0.525，P<0.001）。这些发现证明了双相情感障碍患者气质特质改变可能存在功能性神经影像学基础。
