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一种预测模型揭示了老年脑血管意外患者经桡动脉途径脑血管造影术后血管并发症的独立危险因素。

A predictive model discloses independent risk factors for vascular complications in elderly cerebrovascular accident patients after trans-radial access cerebral angiography.

作者信息

Wang Yao, Yang Lingli, Li Xin, Gu Bei

机构信息

Department of Brain Disease, Lianyungang Affiliated Hospital of Nanjing University of Chinese Medicine Lianyungang 222004, Jiangsu, China.

出版信息

Am J Transl Res. 2025 Apr 15;17(4):2872-2884. doi: 10.62347/DYLC6571. eCollection 2025.

Abstract

OBJECTIVE

To identify the risk factors for vascular complications after total cerebral angiography by trans-radial access (TRA) in elderly cerebrovascular accident (CVA) patients and develop a predictive model.

METHODS

Data from 248 elderly CVA patients at Lianyungang Affiliated Hospital from December 2021 to March 2024 were retrospectively analyzed. The patients were divided into two groups: complicated (those with vascular complications) and non-complicated (those without vascular complications). Clinical data were collected and analyzed. Risk factors were identified using multifactorial logistic regression.

RESULTS

A total of 62 patients experienced vascular complications. Independent risk factors included intraoperative heparin dosage, number of radial artery punctures, timing of surgery, surgical time, mode of pressure hemostasis, duration of pressure hemostasis, and postoperative HAS-BLED (hypertension, abnormal renal/liver function, stroke, bleeding history or predisposition, labile international normalized ratio, elderly, drugs/alcohol concomitantly) score (P<0.05). The nomogram model for predicting complications showed a good Hosmer-Lemeshow fit (χ=2.099, =0.978). Receiver operating characteristic analysis revealed an area under the curve of 0.868 [95% confidence interval (CI) (0.800, 0.936)] for the training set and 0.822 [95% CI (0.723, 0.921)] for the validation set. Decision curve analysis showed a net benefit >0 in both sets within certain risk thresholds.

CONCLUSIONS

Vascular complications following total cerebral angiography by TRA in elderly CVA patients are associated with multiple factors. The nomogram model developed from these risk factors has significant predictive value.

摘要

目的

识别老年脑血管意外(CVA)患者经桡动脉途径(TRA)全脑血管造影术后血管并发症的危险因素,并建立预测模型。

方法

回顾性分析2021年12月至2024年3月在连云港附属医院的248例老年CVA患者的数据。将患者分为两组:并发症组(有血管并发症者)和非并发症组(无血管并发症者)。收集并分析临床数据。采用多因素逻辑回归识别危险因素。

结果

共有62例患者发生血管并发症。独立危险因素包括术中肝素用量、桡动脉穿刺次数、手术时机、手术时间、压迫止血方式、压迫止血持续时间以及术后HAS - BLED(高血压、肾/肝功能异常、卒中、出血史或易感性、国际标准化比值不稳定、老年、同时使用药物/酒精)评分(P<0.05)。预测并发症的列线图模型显示出良好的Hosmer - Lemeshow拟合度(χ=2.099,=0.978)。受试者工作特征分析显示,训练集的曲线下面积为0.868 [95%置信区间(CI)(0.800,0.936)],验证集的曲线下面积为0.822 [95%CI(0.723,0.921)]决策曲线分析表明,在一定风险阈值内,两组的净效益均>0。

结论

老年CVA患者经TRA全脑血管造影术后的血管并发症与多种因素相关。由这些危险因素建立的列线图模型具有显著的预测价值。

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