Tanaka M, Yonekura R, Iio T, Tabata T
Lipids. 1985 Jan;20(1):46-8. doi: 10.1007/BF02534362.
The diurnal variation in lysosomal acid cholesteryl ester hydrolase (Acid CEH), (EC 3.1.1.13) has been examined in fed, fasted and adrenalectomized rats. The Acid CEH activity of normal rat liver exhibits a diurnal rhythm with maxima at 06.00 hours and minima at 18.00 hours, but such a rhythm was not observed in spleen and brain. This rhythm was abolished after fasting for two days, and the resulting Acid CEH activity remained constant at the minimum level. However, adrenalectomy did not abolish the diurnal rhythm. These results indicate that the Acid CEH activity varies according to a diurnal rhythm with maxima and minima separated by approximately 12 hr. Further, it is evident that the appearance of this rhythm is dependent upon dietary, but not adrenal hormone influence.
已对喂食、禁食和肾上腺切除的大鼠体内溶酶体酸性胆固醇酯水解酶（酸CEH，EC 3.1.1.13）的昼夜变化进行了研究。正常大鼠肝脏的酸CEH活性呈现昼夜节律，在06:00时达到最大值，在18:00时达到最小值，但在脾脏和大脑中未观察到这种节律。禁食两天后这种节律消失，由此产生的酸CEH活性在最低水平保持恒定。然而，肾上腺切除并未消除昼夜节律。这些结果表明，酸CEH活性根据昼夜节律而变化，最大值和最小值相隔约12小时。此外，很明显这种节律的出现取决于饮食，而非肾上腺激素的影响。
