Ganul V L, Tydek'skaia I L, Abaliaeva N A, Belous Zh V
Antibiotiki. 1977 Mar;22(3):219-22.
Sensitivity of the microflora of the oncological patients' wounds to the new antibiotics, such as gentamicin, kanamycin, oxacillin, ampicillin and lincomycin was studied with the help of the disc method. The discs with the above antibiotics were prepared under laboratory conditions in accordance with the respective instructions in the WHO. Sensitivity of 429 bacterial cultures, including 98 cultures of pathogenic staphylocci, 45 cultures of Enterococci, 43 hemolytic streptococci, 143 cultures of Escherichia, 50 cultures of Ps. aeruginosa and 50 cultures of Proteus was determined. The studies showed that gentamicin was the most active antibiotic aganist all the microbial species isolated from the surgical and other wounds of oncological patients. It may be used in treatment of the infections caused by association of the microbes belonging to different species, as well as in treatment of purulent processes before elucidating their etiology, 16.7 per cent of the Enterococcal isolates were resistant to gentamicin. Monomycin, kanamycin, oxacillin, lincomycin and macrolide antibiotics at present are sufficiently active against pathogenic staphylococci and hemolytic streptococci.
采用纸片法研究了肿瘤患者伤口微生物群落对新抗生素如庆大霉素、卡那霉素、苯唑西林、氨苄西林和林可霉素的敏感性。含上述抗生素的纸片是在实验室条件下按照世界卫生组织的相应说明制备的。测定了429株细菌培养物的敏感性，其中包括98株致病性葡萄球菌培养物、45株肠球菌培养物、43株溶血性链球菌、143株大肠杆菌培养物、50株铜绿假单胞菌培养物和50株变形杆菌培养物。研究表明，庆大霉素是对从肿瘤患者手术伤口及其他伤口分离出的所有微生物种类最具活性的抗生素。它可用于治疗由不同种类微生物联合引起的感染，以及在明确病因之前治疗化脓性病变，16.7%的肠球菌分离株对庆大霉素耐药。目前，新霉素、卡那霉素、苯唑西林、林可霉素和大环内酯类抗生素对致病性葡萄球菌和溶血性链球菌有足够的活性。
