Johnston Niall, Rockliff Bradley, Duguid Robert, Palasanthiran Pamela, Bartlett Adam W, Willams Phoebe Cm, McMullan Brendan J
Department of Infectious Diseases, Sydney Children's Hospital, Randwick, NSW, Australia.
Faculty of Medicine and Health, UNSW Sydney, NSW, Australia.
Med Mycol Case Rep. 2025 Apr 25;48:100704. doi: 10.1016/j.mmcr.2025.100704. eCollection 2025 Jun.
Available online We report a case of limb-threatening elbow infection in a 3-year-old immunocompetent boy following a closed fracture. Resolution of infection was achieved following combined aggressive debridement, combined antifungal therapy, voriconazole-loaded bone cement, and antiseptic joint irrigation. This highlights the need for early diagnosis and multi-modal surgical, medical and other novel adjunctive therapies in managing these difficult-to-treat infections. Increased research and improved access to novel antifungal drugs are essential to enhance treatment options for intrinsically multidrug-resistant fungal infections.
在线发表 我们报告一例3岁免疫功能正常男孩在闭合性骨折后发生威胁肢体的肘部感染病例。通过积极清创、联合抗真菌治疗、含伏立康唑的骨水泥及关节灌洗抗菌治疗，感染得以消退。这凸显了在处理这些难治性感染时早期诊断及多模式手术、药物及其他新型辅助治疗的必要性。加强研究并改善新型抗真菌药物的可及性对于增加治疗固有耐多药真菌感染的选择至关重要。
