Weiner Jeffrey D, Khoshniyati Sara, Pierog Olivia, Rozati Sima
Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, USA.
Cureus. 2025 Apr 17;17(4):e82457. doi: 10.7759/cureus.82457. eCollection 2025 Apr.
Granulomatous rosacea (GR) is a rare and challenging subtype of rosacea that resists conventional therapies. Here, we present the case of a 56-year-old woman with a two-decade history of treatment-refractory GR who experienced significant clinical improvement with topical ruxolitinib, a Janus kinase (JAK) inhibitor, formulated as a 1.5% cream applied twice daily. After failing multiple established treatments, the patient achieved near-complete resolution of her condition following 10 months of combination therapy with topical ruxolitinib and metronidazole cream. This case highlights the potential efficacy of topical JAK inhibitors as a novel therapeutic approach for recalcitrant GR.
肉芽肿性酒渣鼻（GR）是酒渣鼻的一种罕见且具有挑战性的亚型，对传统疗法有抵抗性。在此，我们报告一例56岁女性患者，她有二十年治疗抵抗性GR病史，使用局部用鲁索替尼（一种Janus激酶（JAK）抑制剂，制成1.5%乳膏，每日涂抹两次）后临床症状有显著改善。在多种既定治疗方法失败后，该患者在局部用鲁索替尼和甲硝唑乳膏联合治疗10个月后病情几乎完全缓解。该病例突出了局部用JAK抑制剂作为顽固性GR的一种新型治疗方法的潜在疗效。
