Chen Bancheng, Wu Chenchen, Liao Yan, Hu Hao, Liu Xiaojuan, Chen Chao, Liu Xiaoming, Wu Lin, Chen Xiaofan, Yu Bo
Department of Dermatology, Peking University Shenzhen Hospital, Shenzhen, 518036, Guangdong Province, China.
Shenzhen Key Laboratory for Translational Medicine of Dermatology, Biomedical Research Institute, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Shenzhen, 518036, Guangdong Province, China.
Arch Dermatol Res. 2025 Feb 13;317(1):398. doi: 10.1007/s00403-025-03915-7.
Rosacea is a chronic skin condition characterized by facial erythema, flushing, and telangiectasia. Abnormalities in the vascular responses are associated with the development of rosacea. Our analysis of the GSE65914 dataset revealed differential expression of angiogenesis-related genes in rosacea lesions classified rosacea samples with distinct angiogenic molecular patterns. Further investigation of immune infiltration characteristics across angiogenic patterns identified unique immune signatures associated with VEGFA MMP9 and VEGFA MMP9 subtypes. Moreover, STAT2 proteins were higher in the VEGFA MMP9 pattern group. Increased expression of STAT2 was confirmed in rosacea patients and in the mice model of rosacea induced by LL37. Knockdown of STAT2 suppressed the tube formation ability of human umbilical vein endothelial cells, which implicated STAT2 participated in regulating angiogenic responses. In conclusion, our study characterized rosacea subtypes by distinct angiogenic molecular patterns and found that STAT2 may play a critical role in the regulation of angiogenic responses in rosacea. These insights may provide a promising target of rosacea therapies.
酒渣鼻是一种慢性皮肤疾病，其特征为面部红斑、潮红和毛细血管扩张。血管反应异常与酒渣鼻的发展有关。我们对GSE65914数据集的分析揭示了酒渣鼻病变中血管生成相关基因的差异表达，将酒渣鼻样本分类为具有不同血管生成分子模式的样本。对不同血管生成模式下免疫浸润特征的进一步研究确定了与VEGFA MMP9和VEGFA MMP9亚型相关的独特免疫特征。此外，STAT2蛋白在VEGFA MMP9模式组中含量更高。在酒渣鼻患者和由LL37诱导的酒渣鼻小鼠模型中证实了STAT2表达增加。敲低STAT2可抑制人脐静脉内皮细胞的管形成能力，这表明STAT2参与调节血管生成反应。总之，我们的研究通过不同的血管生成分子模式对酒渣鼻亚型进行了特征描述，并发现STAT2可能在酒渣鼻血管生成反应的调节中起关键作用。这些见解可能为酒渣鼻治疗提供一个有前景的靶点。
