Stoll D, Cines D B, Aster R H, Murphy S
Blood. 1985 Mar;65(3):584-8.
We studied ten normal subjects and 20 patients with stable, untreated idiopathic thrombocytopenic purpura (ITP) and platelet counts in the range of 35,000 to 110,000/microL. The diagnosis was made by clinical criteria. Platelet-associated IgG was increased in all nine of the nine patients studied. Autologous platelets were labeled with chromium 51 and reinfused for measurement of mean cell life and platelet production rate. Mean cell life was calculated by two methods, weighted mean and multiple hit, with excellent agreement between the two. As expected, mean cell life was significantly reduced in ITP patients as compared to the normal subjects (2.9 days v. 8.0 days, P less than .001). However, mean platelet production rates in ITP patients and normal subjects, 3.5 and 3.8 X 10(9) platelets/k/d respectively, were not significantly different. Platelet production rate was above and below the normal range (2 to 5.6 X 10(9) platelets/k/d) in two and four patients, respectively. We conclude that the rate of platelet production is not increased in most patients with ITP who have platelet counts greater than 35,000/microL. We did find that platelet size was increased in eight of the 12 patients in whom it was measured, including two of the patients with low platelet production.
我们研究了10名正常受试者以及20名患有稳定、未经治疗的特发性血小板减少性紫癜（ITP）且血小板计数在35,000至110,000/微升范围内的患者。诊断依据临床标准做出。在所研究的9名患者中，所有患者的血小板相关IgG均升高。用铬51标记自体血小板并回输，以测量平均细胞寿命和血小板生成率。平均细胞寿命通过加权平均和多次打击两种方法计算，两种方法之间具有极好的一致性。正如预期的那样，与正常受试者相比，ITP患者的平均细胞寿命显著缩短（2.9天对8.0天，P小于0.001）。然而，ITP患者和正常受试者的平均血小板生成率分别为3.5和3.8×10⁹个血小板/千克/天，无显著差异。分别有2名和4名患者的血小板生成率高于和低于正常范围（2至5.6×10⁹个血小板/千克/天）。我们得出结论，大多数血小板计数大于35,000/微升的ITP患者的血小板生成率并未增加。我们确实发现，在测量血小板大小的12名患者中，有8名患者的血小板大小增加，其中包括2名血小板生成率低的患者。
