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一例对托法替布反应良好的重度泛发性环状肉芽肿病例。

A Case of Severe Generalized Granuloma Annulare Responding Well to Tofacitinib.

作者信息

Al-Zahawi Saman, Ghandi Narges, Azhari Vahidesadat, Balighi Kamran

机构信息

Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences (TUMS), Tehran, Iran.

Autoimmune Bullous Diseases Research Center, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.

出版信息

Case Rep Dermatol Med. 2025 May 10;2025:3593724. doi: 10.1155/crdm/3593724. eCollection 2025.

DOI:10.1155/crdm/3593724
PMID:40386505
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12085244/
Abstract

Granuloma annulare is a noninfectious, granulomatous skin disorder that typically presents as symmetrical, asymptomatic, annular, or arciform plaques with slightly raised edges, often found on the back of the hands or feet. This report highlights the successful use of tofacitinib in treating resistant/generalized granuloma annulare in a 66-year-old male with a known history of hepatitis B, demonstrating its potential as an effective therapeutic option.

摘要

环状肉芽肿是一种非感染性的肉芽肿性皮肤病，通常表现为对称、无症状的环状或弧形斑块，边缘略有隆起，常见于手背或足部。本报告强调了托法替布在治疗一名有乙型肝炎病史的66岁男性耐药/泛发性环状肉芽肿中的成功应用，证明了其作为一种有效治疗选择的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0483/12085244/538ac6c0af8c/CRIDM2025-3593724.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0483/12085244/966b3cf06298/CRIDM2025-3593724.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0483/12085244/81344ae49cb2/CRIDM2025-3593724.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0483/12085244/538ac6c0af8c/CRIDM2025-3593724.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0483/12085244/966b3cf06298/CRIDM2025-3593724.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0483/12085244/81344ae49cb2/CRIDM2025-3593724.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0483/12085244/538ac6c0af8c/CRIDM2025-3593724.003.jpg

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本文引用的文献

1
Therapeutic success of tofacitinib in granuloma annulare: A retrospective case series of 15 patients.托法替布治疗环状肉芽肿的疗效：15例患者的回顾性病例系列研究
Indian J Dermatol Venereol Leprol. 2025 Jan-Feb;91(1):65-70. doi: 10.25259/IJDVL_215_2024.
2
Apremilast for the treatment of generalized granuloma annulare: A case series of 8 patients.阿普司特治疗泛发性环状肉芽肿：8例病例系列报道
JAAD Case Rep. 2023 Jun 17;38:59-60. doi: 10.1016/j.jdcr.2023.06.011. eCollection 2023 Aug.
3
A case of generalized granuloma annulare treated with upadacitinib.
1例用乌帕替尼治疗的泛发性环状肉芽肿。
JAAD Case Rep. 2023 Feb 11;34:12-14. doi: 10.1016/j.jdcr.2023.01.027. eCollection 2023 Apr.
4
Treatment of generalized granuloma annulare with dupilumab.使用度普利尤单抗治疗泛发性环状肉芽肿。
J Dermatolog Treat. 2023 Dec;34(1):2186158. doi: 10.1080/09546634.2023.2186158.
5
Rapid improvement of refractory generalized granuloma annulare with the Janus kinase inhibitor baricitinib in two patients.两例患者使用JAK激酶抑制剂巴瑞替尼后难治性泛发性环状肉芽肿迅速改善
Clin Exp Dermatol. 2023 Mar 22;48(4):375-376. doi: 10.1093/ced/llac110.
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Two cases of generalized granuloma annulare successfully treated with an excimer laser.两例泛发性环状肉芽肿经准分子激光治疗成功。
J Dermatol. 2023 May;50(5):e155-e156. doi: 10.1111/1346-8138.16675. Epub 2022 Dec 20.
7
Generalized Granuloma Annulare Associated With Dupilumab Therapy.与度普利尤单抗治疗相关的泛发性环状肉芽肿
Cureus. 2022 Jul 29;14(7):e27439. doi: 10.7759/cureus.27439. eCollection 2022 Jul.
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Generalized granuloma annulare after COVID-19 vaccination.新冠病毒疫苗接种后出现的泛发性环状肉芽肿。
JAAD Case Rep. 2022 May 14;25:18-21. doi: 10.1016/j.jdcr.2022.05.003. eCollection 2022 Jul.
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JAAD Case Rep. 2022 Apr 14;24:38-41. doi: 10.1016/j.jdcr.2022.04.006. eCollection 2022 Jun.
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