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去甲肾上腺素给药剂量、降钙素原（PCT）及血乳酸对感染性休克的诊断价值

Diagnostic values of noradrenaline administered dose, procalcitonin (PCT) and blood lactic acid for septic shock.

作者信息

Ding Lili, Liu Mengru, Sun Haijun

机构信息

Suqian First Hospital, Department of Critical Care Medicine, Suqian, China.

出版信息

J Med Biochem. 2025 Mar 21;44(2):319-329. doi: 10.5937/jomb0-53853.

DOI:10.5937/jomb0-53853
PMID:40386512
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12085186/
Abstract

BACKGROUND

Sepsis/septic shock is a life-threatening condition that requires prompt and effective treatment. Noradrenaline is a widely used vasopressor to manage septic shock, but its optimal dosage remains unclear. This study aimed to investigate the effects of noradrenaline doses on the prognosis of patients with sepsis/septic shock and identify the influencing factors for patient survival.

METHODS

A retrospective study was conducted on 126 patients with sepsis/septic shock who received noradrenaline treatment in the intensive care unit (ICU). Patients were divided into survival (n=91) and death (n=35) groups. Clinical data, laboratory results, and noradrenaline doses were collected and compared between the two groups.

摘要

背景

脓毒症/脓毒性休克是一种危及生命的病症，需要迅速且有效的治疗。去甲肾上腺素是用于治疗脓毒性休克的一种广泛使用的血管加压药，但其最佳剂量仍不明确。本研究旨在探讨去甲肾上腺素剂量对脓毒症/脓毒性休克患者预后的影响，并确定影响患者生存的因素。

方法

对126例在重症监护病房（ICU）接受去甲肾上腺素治疗的脓毒症/脓毒性休克患者进行了一项回顾性研究。患者被分为生存组（n = 91）和死亡组（n = 35）。收集并比较两组患者的临床资料、实验室检查结果及去甲肾上腺素剂量。

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本文引用的文献

1
Tools for Screening, Predicting, and Evaluating Sepsis and Septic Shock: A Comprehensive Review.脓毒症和脓毒性休克的筛查、预测及评估工具：一项全面综述
Cureus. 2024 Aug 18;16(8):e67137. doi: 10.7759/cureus.67137. eCollection 2024 Aug.
2
Development of a Clinical Score for Predicting 28-Day Mortality in Geriatric Sepsis Patients; a Cohort study.老年脓毒症患者28天死亡率预测临床评分系统的开发：一项队列研究
Arch Acad Emerg Med. 2024 Jun 29;12(1):e56. doi: 10.22037/aaem.v12i1.2269. eCollection 2024.
3
The impact of norepinephrine dose reporting heterogeneity on mortality prediction in septic shock patients.
去甲肾上腺素剂量报告异质性对脓毒性休克患者死亡率预测的影响。
Crit Care. 2024 Jul 3;28(1):216. doi: 10.1186/s13054-024-05011-0.
4
Basal procalcitonin, C-reactive protein, interleukin-6, and presepsin for prediction of mortality in critically ill septic patients: a systematic review and meta-analysis.基础降钙素原、C反应蛋白、白细胞介素-6和可溶性髓系细胞触发受体-1用于预测重症脓毒症患者的死亡率：一项系统评价和荟萃分析。
Diagn Progn Res. 2023 Aug 3;7(1):15. doi: 10.1186/s41512-023-00152-2.
5
A randomized study for dosimetric assessment and clinical impact of bone marrow sparing intensity-modulated radiation therapy versus 3-dimensional conformal radiation therapy on hematological and gastrointestinal toxicities in cervical cancer.一项针对宫颈癌调强放疗与三维适形放疗在骨髓保护方面的剂量学评估和临床影响的随机研究：对血液学和胃肠道毒性的影响。
J Cancer Res Ther. 2022 Oct-Dec;18(6):1490-1497. doi: 10.4103/jcrt.JCRT_1242_20.
6
cellulitis, bacteremia, and sepsis in a patient with liver cirrhosis and end-stage renal disease following a minor abrasion with exposure to pond water: A case report and literature review.肝硬化和终末期肾病患者在轻微擦伤并接触池塘水后发生蜂窝织炎、菌血症和脓毒症：病例报告及文献综述
IDCases. 2022 Nov 8;30:e01631. doi: 10.1016/j.idcr.2022.e01631. eCollection 2022.
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