Bao Junjie, Zha Yutao, Chen Shi, Yuan Jun, Qiao Jiejie, Cao Limian, Yang Qigang, Liu Miao, Shao Min
Department of Critical Medicine, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
School of Public Health, North China University of Science and Technology, Tangshan, Hebei, China.
Heliyon. 2022 Nov 5;8(11):e11409. doi: 10.1016/j.heliyon.2022.e11409. eCollection 2022 Nov.
To study the importance of LMAN2 in septic shock and prognosis prediction in sepsis patients.
Serum LMAN2 was measured by ELISA in 109 sepsis patients within 24 h after their admission to ICU. We also collected clinical and laboratory variables.
Compared with sepsis group (1.21 (1.05) ng/ml), serum LMAN2 level was significantly higher in patients with septic shock (1.75 (2.04) ng/ml) on the day of admission to the ICU ( < 0.001), and serum LMAN2 level were significantly higher in the sepsis non-survival group (1.91 (1.66) ng/ml) than in the survival group (1.15 (1.17) ng/ml). COX regression analysis showed that high serum LMAN2 level (>1.28 ng/ml) was a predictor of 28-day mortality in sepsis patients.
This study shows that high serum LMAN2 level may indicate septic shock and is associated with an unfavorable prognosis for sepsis patients.
研究LMAN2在脓毒症休克中的重要性及对脓毒症患者预后的预测作用。
采用酶联免疫吸附测定法（ELISA）检测109例入住重症监护病房（ICU）24小时内的脓毒症患者血清LMAN2水平。我们还收集了临床和实验室变量。
与脓毒症组（1.21（1.05）ng/ml）相比，脓毒症休克患者入住ICU当天的血清LMAN2水平（1.75（2.04）ng/ml）显著更高（P<0.001），且脓毒症死亡组的血清LMAN2水平（1.91（1.66）ng/ml）显著高于存活组（1.15（1.17）ng/ml）。COX回归分析表明，高血清LMAN2水平（>1.28 ng/ml）是脓毒症患者28天死亡率的预测指标。
本研究表明，高血清LMAN2水平可能提示脓毒症休克，并与脓毒症患者不良预后相关。
