Leng Tomas, Karakus Ibrahim Serhat
Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA.
Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA.
J Crit Care Med (Targu Mures). 2025 Apr 30;11(2):192-195. doi: 10.2478/jccm-2024-0046. eCollection 2025 Apr.
Brain abscess is a serious condition in children, leading to rapid deterioration, and permanent neurological damage associated with significant morbidity and mortality. Current management protocols for brain abscesses focus on intravenous antibiotics and surgical excision and drainage.
A 12-year-old adolescent male who had headache and photophobia and was diagnosed with multiple brain abscesses and was refractory to conventional medical and neurosurgical intervention. A single dose of 10 mg vancomycin was administered through endo-ventricular drain, resulting in resolution of abscesses and alleviation of symptoms.
We describe the first instance of intraventricular vancomycin use in the pediatric age group for the treatment of multiple brain abscesses. Given the variability in dosing reported in the literature, our case report warrants further studies to standardize dosage for this rare intervention.
脑脓肿是儿童的一种严重疾病，可导致病情迅速恶化，并伴有严重的发病率和死亡率的永久性神经损伤。目前脑脓肿的治疗方案主要集中在静脉使用抗生素以及手术切除和引流。
一名12岁青少年男性，出现头痛和畏光症状，被诊断为多发性脑脓肿，对传统药物和神经外科干预均无效。通过脑室内引流管给予单剂量10毫克万古霉素，脓肿得以消退，症状得到缓解。
我们描述了在儿科年龄组中首次使用脑室内万古霉素治疗多发性脑脓肿的案例。鉴于文献报道的剂量存在差异，我们的病例报告值得进一步研究，以规范这种罕见干预措施的剂量。
