Segal Galya, Keidar Noam, Herskovitz Moshe, Yaniv Yael
Laboratory of Bioelectric and Bioenergetic Systems, Faculty of Biomedical Engineering, Technion-Israel Institute of Technology, Haifa, Israel.
Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
Front Neurosci. 2025 May 2;19:1526963. doi: 10.3389/fnins.2025.1526963. eCollection 2025.
Better understanding of ictogenesis may allow clinical interventions and potentially reduce the impact of epilepsy on patients' quality of life. This study aims to characterize the EEG changes during the preictal period.
This work retrospectively analyzed long-term scalp EEG recordings collected at two neurology centers to characterize preictal activity (start point and duration) for each seizure using EEG features. A channel selection algorithm was implemented and localized preictal activity.
Out of 19 patients, 17 (89.5%) had a distinct preictal pattern, starting 83 ± 60 min before seizure onset and lasting 56 ± 47 min. Spectral Entropy and Hjorth mobility were consistently two out of the three features best distinguished preictal from interictal activity. The third distinguishing feature was either theta power, delta power, beta power, or gamma power. Preictal activity before two seizures in the same patient shared common electrodes and features but differed in duration and timing.
Preictal activity, defined as prolonged intervals of uncommon EEG activity, varies in time, localization and signal patterns between individuals and varies in timing and duration between seizures of the same individual.
更好地理解癫痫发作的起源可能有助于临床干预，并有可能减轻癫痫对患者生活质量的影响。本研究旨在描述发作前期脑电图（EEG）的变化特征。
这项工作回顾性分析了在两个神经科中心收集的长期头皮脑电图记录，以利用脑电图特征描述每次癫痫发作的发作前期活动（起始点和持续时间）。实施了一种通道选择算法并定位发作前期活动。
在19名患者中，17名（89.5%）有明显的发作前期模式，在癫痫发作开始前83±60分钟开始，持续56±47分钟。谱熵和 Hjorth 活动度始终是最能区分发作前期和发作间期活动的三个特征中的两个。第三个区分特征是θ波功率、δ波功率、β波功率或γ波功率。同一患者两次癫痫发作前的发作前期活动共用相同的电极和特征，但持续时间和时间不同。
发作前期活动定义为脑电图活动异常的延长间期，在个体之间的时间、定位和信号模式上有所不同，在同一个体的不同癫痫发作之间的时间和持续时间也有所不同。
