Pedersen Mangor, Pardoe Heath, Mito Remika, Sethi Moksh, Vaughan David N, Carney Patrick W, Jackson Graeme D
Department of Psychology and Neuroscience, Auckland University of Technology (AUT), Auckland 0627, New Zealand.
The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne 3010, Australia.
Brain Commun. 2024 Sep 20;6(5):fcae328. doi: 10.1093/braincomms/fcae328. eCollection 2024.
After a first epileptic seizure, anti-seizure medications (ASMs) can change the likelihood of having a further event. This prospective study aimed to quantify brain network changes associated with taking ASM monotherapy. We applied graph theoretical network analysis to longitudinal resting-state functional MRI (fMRI) data from 28 participants who had recently experienced their first seizure. Participants were imaged before and during long-term ASM therapy, with a mean inter-scan interval of 6.9 months. After commencing ASM, we observed an increase in the clustering coefficient and a decrease in network path length. Brain changes after ASM treatment were most prominent in the superior frontoparietal and inferior fronto-temporal regions. Participants with recurrent seizures display the most pronounced network changes after ASM treatment. This study shows changes in brain network function after ASM administration, particularly in participants with recurrent seizures. Larger studies that ideally include control cohorts are required to understand further the connection between ASM-related brain network changes and longer-term seizure status.
首次癫痫发作后，抗癫痫药物（ASMs）会改变再次发作的可能性。这项前瞻性研究旨在量化与采用ASM单一疗法相关的脑网络变化。我们将图论网络分析应用于28名近期首次发作的参与者的纵向静息态功能磁共振成像（fMRI）数据。参与者在长期ASM治疗前和治疗期间进行成像，平均扫描间隔为6.9个月。开始使用ASM后，我们观察到聚类系数增加，网络路径长度缩短。ASM治疗后脑变化在额顶叶上部和额颞叶下部区域最为明显。复发癫痫的参与者在ASM治疗后显示出最明显的网络变化。这项研究显示了ASM给药后脑网络功能的变化，特别是在复发癫痫的参与者中。需要开展更大规模的研究（理想情况下包括对照队列），以进一步了解与ASM相关的脑网络变化和长期癫痫状态之间的联系。
