Suppr超能文献

用于预测创伤性腹部和盆腔损伤干预措施及预后的FASILA评分的验证:一项前瞻性临床研究

Validation of the FASILA Score for Predicting Interventions and Outcomes in Traumatic Abdominal and Pelvic Injuries: A Prospective Clinical Study.

作者信息

El-Menyar Ayman, Ramzee Ahmed F, Elmegabar Basel H, Asim Mohammad, Peralta Ruben, Verma Vishwajit, Abdelrahman Husham, Jogol Hisham, Afzal Muniba, Abdulrahman Yasir, Abdurraheim Nuri, Kanbar Ahad, Siddiqui Tariq, Rizoli Sandro, Al-Thani Hassan

机构信息

Clinical Research, Trauma and Vascular Surgery, Hamad Medical Corporation (HMC), Doha, Qatar.

Clinical Medicine, Weill Cornell Medical College, Doha, Qatar.

出版信息

World J Surg. 2025 Jul;49(7):1951-1959. doi: 10.1002/wjs.12632. Epub 2025 May 19.

Abstract

BACKGROUND

The FASILA score is a 7-point scale comprising the FAST (focused assessment with sonography in trauma), shock index, and serum lactate. We aimed to validate this score prospectively in patients with abdominal and pelvic trauma to predict the need for massive blood transfusion, laparotomy, and inhospital mortality.

METHODS

This prospective study included all adult patients who sustained abdominal and/or pelvic trauma. Pediatric patients, prehospital cardiac arrest, and severe head injury were excluded. Data were analyzed and compared with low (< 4) versus high (≥ 4) FASILA scores.

RESULTS

A total of 400 patients (mean age 36.3 ± 12.7; 90% male; and 96% had blunt trauma) were enrolled between 2022 and 2024. Patients with higher FASILA scores (19.3%) had higher rates of exploratory laparotomy and radiological interventions and received more blood transfusions. They also had longer hospital stays, higher rates of sepsis, and mortality (p = 0.001). The FASILA scores significantly correlated with shock index (r = 0.75), ISS (r = 0.38), SOFA score (r = 0.36), and abdominal AIS (r = 0.27), TRISS (r = -0.19), RTS (r = -0.26), and fibrinogen levels (r = -0.12). A FASILA score ≥ 4 had a high specificity (85.5%) and negative predictive value (80%) for predicting the need for surgery. The FASILA score was an independent predictor of blood transfusion (odds ratio 1.92 and 95% CI 1.43-2.58) after adjusting for abdominal AIS, ISS, SOFA score, and fibrinogen level. AUROC curves were better for the FASILA score than ABC score and "SI alone" for the prediction of MTP and surgical interventions.

CONCLUSION

The significant association between high FASILA scores and blood transfusions, surgical interventions, and mortality indicates its usefulness in early risk stratification in abdominopelvic trauma. Multicenter studies are recommended to enhance external validity across diverse populations and settings.

摘要

背景

FASILA评分是一个7分制量表,由FAST(创伤超声重点评估)、休克指数和血清乳酸组成。我们旨在对腹部和盆腔创伤患者进行前瞻性验证,以预测大量输血、剖腹手术和住院死亡率的需求。

方法

这项前瞻性研究纳入了所有遭受腹部和/或盆腔创伤的成年患者。排除儿科患者、院前心脏骤停和严重颅脑损伤患者。对数据进行分析,并比较FASILA评分低(<4)与高(≥4)的情况。

结果

2022年至2024年期间共纳入400例患者(平均年龄36.3±12.7岁;90%为男性;96%为钝性创伤)。FASILA评分较高的患者(19.3%)进行探查性剖腹手术和放射学干预的比率更高,接受的输血更多。他们的住院时间也更长,败血症发生率和死亡率更高(p=0.001)。FASILA评分与休克指数(r=0.75)、损伤严重度评分(ISS,r=0.38)、序贯器官衰竭评估(SOFA)评分(r=0.36)、腹部简明损伤定级(AIS,r=0.27)、创伤严重度特征评分(TRISS,r=-0.19)、修订创伤评分(RTS,r=-0.26)和纤维蛋白原水平(r=-0.12)显著相关。FASILA评分≥4对于预测手术需求具有较高的特异性(85.5%)和阴性预测值(80%)。在调整腹部AIS、ISS、SOFA评分和纤维蛋白原水平后,FASILA评分是输血的独立预测因素(比值比1.92,95%置信区间1.43-2.58)。在预测大量输血和手术干预方面,FASILA评分的受试者工作特征曲线(AUROC)比ABC评分和“单独休克指数”更好。

结论

高FASILA评分与输血、手术干预和死亡率之间的显著关联表明其在腹部盆腔创伤早期风险分层中的有用性。建议进行多中心研究,以提高在不同人群和环境中的外部有效性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ae4/12282565/2987c023bf22/WJS-49-1951-g001.jpg

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验