Suppr超能文献

Delta休克指数预测创伤患者的损伤严重程度、干预措施及预后:一项10年回顾性观察研究。

Delta shock index predicts injury severity, interventions, and outcomes in trauma patients: A 10-year retrospective observational study.

作者信息

Asim Mohammad, El-Menyar Ayman, Ahmed Khalid, Al-Ani Mushreq, Mathradikkal Saji, Alaieb Abubaker, Hammo Abdel Aziz, Taha Ibrahim, Kloub Ahmad, Al-Thani Hassan

机构信息

Department of Surgery, Trauma and Vascular Surgery Section, Clinical Research, Hamad Medical Corporation, Doha 3050, Qatar.

Department of Clinical Medicine, Weill Cornell Medicine, PO Box 24144, Doha, Qatar.

出版信息

World J Crit Care Med. 2024 Dec 9;13(4):99587. doi: 10.5492/wjccm.v13.i4.99587.

Abstract

BACKGROUND

Most trauma occurs among young male subjects in Qatar. We examined the predictive values of the delta shock index (DSI), defined as the change in the shock index (SI) value from the scene to the initial reading in the emergency unit (, subtracting the calculated SI at admission from SI at the scene), at a Level 1 trauma center.

AIM

To explore whether high DSI is associated with severe injuries, more interventions, and worse outcomes [, blood transfusion, exploratory laparotomy, ventilator-associated pneumonia, hospital length of stay (HLOS), and in-hospital mortality] in trauma patients.

METHODS

A retrospective analysis was conducted after data were extracted from the National Trauma Registry between 2011 and 2021. Patients were grouped based on DSI as low (≤ 0.1) or high (> 0.1). Data were analyzed and compared using and Student's -tests. Correlations between DSI and injury severity score (ISS), revised trauma score (RTS), abbreviated injury scale (AIS), Glasgow coma scale (GCS), trauma score-ISS (TRISS), HLOS, and number of transfused blood units (NTBU), were assessed using correlation coefficient analysis. The diagnostic testing accuracy for predicting mortality was determined using the validity measures of the DSI. Logistic regression analysis was performed to identify predictors of mortality.

RESULTS

This analysis included 13212 patients with a mean age of 33 ± 14 years, and 24% had a high DSI. Males accounted for 91% of the study population. The trauma activation level was higher in patients with a high DSI (38% 15%, = 0.001). DSI correlated with RTS ( = -0.30), TRISS ( = -0.30), NTBU ( = 0.20), GCS ( = -0.24), ISS ( = 0.22), and HLOS ( = 0.14) ( = 0.001 for all). High DSI was associated with significantly higher rates of intubation, laparotomy, ventilator-associated pneumonia, massive transfusion activation, and mortality than low DSI. For mortality prediction, a high DSI had better specificity, negative predictive value, and negative likelihood ratio (77%, 99%, and 0.49%, respectively). After adjusting for age, emergency medical services time, GCS score, and ISS, multivariable regression analysis showed that DSI was an independent predictor of mortality (odds ratio = 1.9; 95% confidence interval: 1.35-2.76).

CONCLUSION

In addition to sex-biased observations, almost one-quarter of the study cohort had a higher DSI and were mostly young. High DSI correlated significantly with the other injury severity scores, which require more time and imaging to be ready to use. Therefore, DSI is a practical, simple bedside tool for triaging and prognosis in young patients with trauma.

摘要

背景

卡塔尔的大多数创伤发生在年轻男性身上。我们在一家一级创伤中心研究了δ休克指数(DSI)的预测价值,DSI定义为从现场到急诊室初始读数时休克指数(SI)值的变化(用现场的SI值减去入院时计算得出的SI值)。

目的

探讨高DSI是否与创伤患者的重伤、更多干预措施及更差的预后相关(即输血、剖腹探查、呼吸机相关性肺炎、住院时间(HLOS)和院内死亡率)。

方法

从2011年至2021年的国家创伤登记处提取数据后进行回顾性分析。患者根据DSI分为低(≤0.1)或高(>0.1)两组。使用方差分析和学生t检验对数据进行分析和比较。使用相关系数分析评估DSI与损伤严重程度评分(ISS)、修正创伤评分(RTS)、简明损伤定级(AIS)、格拉斯哥昏迷量表(GCS)、创伤评分-ISS(TRISS)、HLOS和输血量(NTBU)之间的相关性。使用DSI的有效性指标确定预测死亡率的诊断测试准确性。进行逻辑回归分析以确定死亡率的预测因素。

结果

该分析纳入了13212例患者,平均年龄为33±14岁,24%的患者DSI较高。男性占研究人群的91%。DSI高的患者创伤激活水平更高(38%对15%,P=0.001)。DSI与RTS(r=-0.30)、TRISS(r=-0.30)、NTBU(r=0.20)、GCS(r=-0.24)、ISS(r=0.22)和HLOS(r=0.14)相关(所有P=0.001)。与低DSI相比,高DSI与插管、剖腹手术、呼吸机相关性肺炎、大量输血激活和死亡率的发生率显著更高相关。对于死亡率预测,高DSI具有更好的特异性、阴性预测值和阴性似然比(分别为77%、99%和0.49%)。在调整年龄、紧急医疗服务时间、GCS评分和ISS后,多变量回归分析表明DSI是死亡率的独立预测因素(优势比=1.9;95%置信区间:1.35-2.76)。

结论

除了有性别差异的观察结果外,近四分之一的研究队列DSI较高,且大多为年轻人。高DSI与其他损伤严重程度评分显著相关,而这些评分需要更多时间和影像学检查才能使用。因此,DSI是一种用于年轻创伤患者分诊和预后评估的实用、简单的床边工具。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0716/11577535/ee4eccd2aab6/99587-g001.jpg

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验