Stefanyszyn M A, Hidayat A A, Flanagan J C
Ophthalmology. 1985 Jan;92(1):120-7. doi: 10.1016/s0161-6420(85)34061-7.
Twenty eyelid specimens from patients with involutional ectropion, obtained by full-thickness horizontal shortening procedures, were examined histopathologically by light and electron microscopy and compared with six normal eyelids from exenteration specimens. Paralytic, cicatricial, and congenital ectropions were excluded from the study. The main histopathologic features included: (1) collagen degeneration and elastosis of the tarsal plate; (2) increased amounts of adipose tissue in the distal tarsus and capsulopalpebral fascia; (3) subacute inflammation and epidermidalization of the tarsal conjunctiva; (4) focal degeneration, fibrosis and elastosis of pretarsal orbicularis, and occasionally minimal change in the muscle of Riolan; and (5) arteriosclerosis of the marginal artery. The combination of these histopathologic changes characterize and may contribute to the development of ectropion of the eyelid associated with aging.
通过全层水平缩短手术获取的20例退行性睑外翻患者的眼睑标本，采用光镜和电镜进行组织病理学检查，并与6例眼球摘除标本中的正常眼睑进行比较。研究排除了麻痹性、瘢痕性和先天性睑外翻。主要组织病理学特征包括：（1）睑板胶原变性和弹性组织变性；（2）睑板远端和睑囊筋膜中脂肪组织增多；（3）睑结膜亚急性炎症和表皮化生；（4）睑前眼轮匝肌局灶性变性、纤维化和弹性组织变性，偶尔里奧朗肌有轻微改变；（5）睑缘动脉动脉硬化。这些组织病理学变化的组合可表征并可能促使与衰老相关的眼睑外翻的发生。
