Karlsson Mats O
Department of Pharmacy, Uppsala University, Uppsala, Sweden.
Clin Pharmacol Ther. 2025 Jun;117(6):1516-1532. doi: 10.1002/cpt.3663.
In the decades preceding 1970s, there were considerable advances in theoretical descriptions of pharmacokinetics, drug action, and the time-course of dose-concentration-response relations. However, delayed drug effects and how to analyze data across individuals still offered a considerable challenge. Sheiner et al., through the formulation of the effect-compartment model, the utilization of nonlinear mixed effects models, and simultaneous PKPD analysis, offered solutions to these issues that still today are considered state-of-the-art.
在20世纪70年代之前的几十年里，药代动力学、药物作用以及剂量-浓度-反应关系的时程的理论描述取得了长足进展。然而，药物延迟效应以及如何对个体间的数据进行分析仍然是一个巨大的挑战。谢纳等人通过建立效应室模型、运用非线性混合效应模型以及同时进行药代动力学-药效学分析，为这些问题提供了至今仍被视为前沿的解决方案。
