Wang Xizhi, Fang Tianxiang, Shen Wenjun
Department of Cardiology, Lihuili Hospital Affiliated to Ningbo University, Ningbo, China.
Health Science Center, Ningbo University, Ningbo, China.
Medicine (Baltimore). 2025 May 16;104(20):e42506. doi: 10.1097/MD.0000000000042506.
Helicobacter pylori (H pylori) infection and H pylori antibodies have been reported to be associated with an increased risk of atrial fibrillation (AF) in several observational studies. However, whether this relationship is causal and which H pylori antibodies serve as the determinant of AF remains largely unclear. Recently published Genome-wide association studies on 7 different antibodies of H pylori-specific proteins and AF (2 correction methods) were included in this study. A two-sample Mendelian randomization study was employed to investigate the causal effects of circulating H pylori antibodies on the risk of AF. Genetically predicted serum H pylori Catalase antibody level was associated with an increased risk of AF (Firth correction) (odds ratio = 1.137, 95% confidence interval: 1.008-1.282, P = .037) and AF (saddlepoint approximation correction) (odds ratio = 1.139, 95% confidence interval: 1.010-1.284, P = .034). No significant causal correlations were found between other H pylori antibodies and AF. This Mendelian randomization study demonstrates that H pylori Catalase antibody is the only causal determinant associated with the risk of AF in terms of H pylori-related antibodies.
在多项观察性研究中，据报道幽门螺杆菌（H pylori）感染及幽门螺杆菌抗体与心房颤动（AF）风险增加有关。然而，这种关系是否为因果关系，以及哪些幽门螺杆菌抗体是房颤的决定因素，在很大程度上仍不清楚。本研究纳入了最近发表的关于幽门螺杆菌特异性蛋白的7种不同抗体与房颤的全基因组关联研究（2种校正方法）。采用两样本孟德尔随机化研究来探讨循环幽门螺杆菌抗体对房颤风险的因果效应。基因预测的血清幽门螺杆菌过氧化氢酶抗体水平与房颤风险增加相关（Firth校正）（比值比 = 1.137，95%置信区间：1.008 - 1.282，P = 0.037）以及房颤（鞍点近似校正）（比值比 = 1.139，95%置信区间：1.010 - 1.284，P = 0.034）。未发现其他幽门螺杆菌抗体与房颤之间存在显著的因果相关性。这项孟德尔随机化研究表明，就幽门螺杆菌相关抗体而言，幽门螺杆菌过氧化氢酶抗体是与房颤风险相关的唯一因果决定因素。
