Department of Internal Medicine B, Ziv Medical Center, The Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel -
Department of Internal Medicine B, Ziv Medical Center, The Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel.
Minerva Gastroenterol (Torino). 2024 Jun;70(2):177-180. doi: 10.23736/S2724-5985.23.03323-5. Epub 2023 Feb 6.
Atrial fibrillation (AF) is the most common rhythm disturbance seen in clinical practice. Evidence emerged that suggested inflammation was associated with risk of AF. Helicobacter pylori (HP) cause gastric and esophageal inflammation, as well as systemic and vascular inflammation. These local and systemic inflammatory effects may increase the risk of AF. The pathogenesis of atrial fibrillation (AF) remains unknown. However, many recent studies point to an association between AF and inflammation because of a demonstrable significant correlation between the dysrhythmia and various biomarkers of inflammation. Given the suggested involvement of inflammation with this dysrhythmia, an initiating factor for inflammation has been sought. Chronic bacterial infection is the most likely event to initiate and maintain an inflammatory process. Recently, bacterial infections have been hypothesized to be involved in the pathogenesis of AF, and Helicobacter pylori and Chlamydia pneumoniae are two bacteria that have aroused interest. The aim of this study was to compare the prevalence of H. Pylori infection, proven by gastric biopsy, between AF patients and control group and the role of CRP, MPV, age and sex in patients with HP associated AF.
We investigated one hundred eighty patients with HP in whom gastroscopy was done and/or urea breathe test because of dyspepsia and epigastric discomfort for eventual detecting the presence of H. pylori infection, and the prevalence of fibrillation in patients with HP, and whether age, sex, inflammatory markers are different in the two groups. The study was enrolled in the Department of Internal Medicine, Ziv Medical Center, Safed, Israel, from 2015 until 2019.
The prevalence is more pronounced in men with both atrial fibrillation and H. pylori, in terms of age we see that the incidence of atrial fibrillation is more relative in the older age P<0.001. There is no statistically significant difference in the inflammatory marker MPV between the two groups P<0.005. The levels of high-sensitivity C-reactive protein (hs-CRP) have been shown to be higher among patients with H. pylori with AF compared with the control group HP without AF statistically significant P<0.001.
There is a correlation between HP and AF, AF is more related to age and to an increased inflammation marker CRP in patients diagnosed with HP.
心房颤动（AF）是临床实践中最常见的节律紊乱。有证据表明，炎症与 AF 的风险相关。幽门螺杆菌（HP）可引起胃和食管炎症，以及全身和血管炎症。这些局部和全身炎症反应可能会增加 AF 的风险。心房颤动（AF）的发病机制尚不清楚。然而，许多最近的研究指出 AF 与炎症之间存在关联，因为心律失常与各种炎症生物标志物之间存在明显的相关性。鉴于炎症与这种心律失常之间的关联，人们一直在寻找炎症的起始因素。慢性细菌感染最有可能引发和维持炎症过程。最近，人们假设细菌感染与 AF 的发病机制有关，幽门螺杆菌和肺炎衣原体是两种引起人们兴趣的细菌。本研究旨在比较经胃活检证实的 AF 患者和对照组中 HP 感染的发生率，以及 CRP、MPV、年龄和性别在 HP 相关 AF 患者中的作用。
我们调查了 180 名因消化不良和上腹部不适而接受胃镜检查和/或尿素呼气试验以检测 HP 感染的 HP 患者，并调查了 HP 患者中房颤的发生率，以及年龄、性别、炎症标志物在两组之间是否存在差异。该研究于 2015 年至 2019 年在以色列塞法德的 Ziv 医疗中心内科进行。
男性中同时患有房颤和 HP 的患者的患病率更为明显，就年龄而言，我们发现房颤的发病率在年龄较大的患者中更为明显，P<0.001。两组之间 MPV 等炎症标志物无统计学差异，P<0.005。与无 AF 的 HP 对照组相比，患有 AF 的 HP 患者的高敏 C 反应蛋白（hs-CRP）水平更高，具有统计学意义，P<0.001。
HP 与 AF 之间存在相关性，AF 与年龄的相关性更大，与诊断为 HP 的患者的炎症标志物 CRP 的升高更相关。
