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空气中存在的问题：一例与持续气道正压通气（CPAP）泡沫降解及吸入综合征相关的间质性肺疾病

There Was Something in the Air: A Case of Interstitial Lung Disease Associated With Continuous Positive Airway Pressure (CPAP) Foam Degradation and Inhalation Syndrome.

作者信息

Valdes Bracamontes Ma D, Dubey Gangacharan

机构信息

Pulmonary and Critical Care, SUNY (State University of New York) Downstate Health Sciences University, Brooklyn, USA.

Pulmonary and Critical Care Medicine, VA NY (Veterans Affairs New York) Harbor Healthcare System, Brooklyn, USA.

出版信息

Cureus. 2025 Apr 19;17(4):e82595. doi: 10.7759/cureus.82595. eCollection 2025 Apr.

DOI:10.7759/cureus.82595
PMID:40390713
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12088699/
Abstract

Polyurethane foam degradation in ventilatory support devices led to a recall by Philips Respironics after users developed respiratory symptoms and noted a sediment in the tubing system of such devices. Foam degradation releases end products that have an irritative effect on the airway. Although the incidence of neoplastic processes did not increase among users, studies for other conditions are scant. The following case presents the association between the use of one of these devices and a new diagnosis of interstitial lung disease, which resolved upon discontinuation of the device, in a patient with obstructive sleep apnea and chronic obstructive pulmonary disease.

摘要

在通气支持设备中，聚氨酯泡沫降解导致飞利浦伟康公司召回产品，此前用户出现呼吸道症状，并注意到此类设备的管路系统中有沉积物。泡沫降解会释放出对气道有刺激作用的终产物。尽管使用者中肿瘤性病变的发生率并未增加，但针对其他病症的研究却很少。以下病例介绍了一名患有阻塞性睡眠呼吸暂停和慢性阻塞性肺疾病的患者，使用其中一种设备与新诊断的间质性肺病之间的关联，停用该设备后病情得到缓解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d4f/12088699/d8ee450ba329/cureus-0017-00000082595-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d4f/12088699/ae1164664c46/cureus-0017-00000082595-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d4f/12088699/b5e984d6a4c8/cureus-0017-00000082595-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d4f/12088699/d8ee450ba329/cureus-0017-00000082595-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d4f/12088699/ae1164664c46/cureus-0017-00000082595-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d4f/12088699/b5e984d6a4c8/cureus-0017-00000082595-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d4f/12088699/d8ee450ba329/cureus-0017-00000082595-i03.jpg

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本文引用的文献

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A particle of concern: explored and proposed underlying mechanisms of microplastic-induced lung damage and pulmonary fibrosis.一个值得关注的微粒：探讨并提出微塑料诱导肺损伤和肺纤维化的潜在机制。
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The impaired response of nasal epithelial cells to microplastic stimulation in asthma and COPD.
哮喘和慢性阻塞性肺疾病中鼻上皮细胞对微塑料刺激的反应受损。
Sci Rep. 2025 Feb 4;15(1):4242. doi: 10.1038/s41598-025-87242-x.
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Microplastic and plastic pollution: impact on respiratory disease and health.微塑料和塑料污染：对呼吸疾病和健康的影响。
Eur Respir Rev. 2024 Jun 12;33(172). doi: 10.1183/16000617.0226-2023. Print 2024 Apr.
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Veterans Health Administration response to 2021 recall of Philips Respironics devices: A case study.退伍军人健康管理局对飞利浦伟康设备2021年召回事件的应对：一项案例研究。
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Potential health risks of sound abatement material in positive airway pressure devices for sleep breathing disorders: a summary of studies to date.用于睡眠呼吸障碍的正压通气设备中消声材料的潜在健康风险：迄今研究综述
Sleep Breath. 2023 Oct;27(5):1925-1927. doi: 10.1007/s11325-022-02763-3. Epub 2022 Dec 15.
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Health risks related to polyurethane foam degradation in CPAP devices used for sleep apnoea treatment.与治疗睡眠呼吸暂停的 CPAP 设备中聚氨酯泡沫降解相关的健康风险。
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