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Investigating the Feasibility and Safety of Osseointegration With Neural Interfaces for Advanced Prosthetic Control.

作者信息

Leung Emma Shiwen, Mofatteh Mohammad

机构信息

Neurosurgery, Neuro International Collaboration (NIC), London, GBR.

School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, GBR.

出版信息

Cureus. 2025 Apr 19;17(4):e82567. doi: 10.7759/cureus.82567. eCollection 2025 Apr.


DOI:10.7759/cureus.82567
PMID:40390719
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12086952/
Abstract

Osseointegrated neural interfaces (ONI), particularly in conjunction with peripheral nerve interfaces (PNIs), have emerged as a promising advancement for intuitive neuroprosthetics. PNIs can decode neural signals and allow precise prosthetic movement control and bidirectional communication for haptic feedback, while osseointegration can address limitations of traditional socket-based prosthetics, such as poor stability, limited dexterity, and lack of sensory feedback.  This review explores advancements in ONIs, including screw-fit and press-fit systems and their integration with PNIs for bidirectional communication. ONIs integrated with PNIs (OIPNIs) have shown improvements in signal fidelity, motor control, and sensory feedback compared to popular surface electromyography (sEMG) systems. Additionally, emerging technologies such as hybrid electrode designs (e.g., cuff and sieve electrode (CASE)) and regenerative peripheral nerve interfaces (RPNIs) show potential for enhancing selectivity and reducing complications such as micromotion and scarring. Despite these advances, challenges remain, including infection risk, electrode degradation, and variability in long-term signal stability.  Osseointegration combined with advanced neural interfaces represents a transformative approach to prosthetic control, offering more natural and intuitive movement with sensory feedback. Further research is needed to address long-term biocompatibility, reduce surgical invasiveness, and explore emerging technologies such as machine learning for personalized ONI designs. The findings of this review underscore the potential of ONIs to enhance embodiment and quality of life for amputees and highlight current pitfalls and possible areas of improvement and future research.

摘要

相似文献

[1]
Investigating the Feasibility and Safety of Osseointegration With Neural Interfaces for Advanced Prosthetic Control.

Cureus. 2025-4-19

[2]
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[3]
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[4]
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[5]
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[6]
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[7]
Micro-channel sieve electrode for concurrent bidirectional peripheral nerve interface. Part B: stimulation.

J Neural Eng. 2018-11-9

[8]
Improving the Selectivity of an Osseointegrated Neural Interface: Proof of Concept For Housing Sieve Electrode Arrays in the Medullary Canal of Long Bones.

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[9]
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[10]
Tissue-Engineered Peripheral Nerve Interfaces.

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本文引用的文献

[1]
Clinical trials for implantable neural prostheses: understanding the ethical and technical requirements.

Lancet Digit Health. 2025-3

[2]
Emerging Value of Osseointegration for Intuitive Prosthetic Control after Transhumeral Amputations: A Systematic Review.

Plast Reconstr Surg Glob Open. 2024-5-28

[3]
Intuitive control of additional prosthetic joints via electro-neuromuscular constructs improves functional and disability outcomes during home use-a case study.

J Neural Eng. 2024-5-21

[4]
Electrical Stimulation of Regenerative Peripheral Nerve Interfaces (RPNIs) Induces Referred Sensations in People With Upper Limb Loss.

IEEE Trans Neural Syst Rehabil Eng. 2024

[5]
Neuromuscular implants: Interfacing with skeletal muscle for improved clinical translation of prosthetic limbs.

Muscle Nerve. 2024-2

[6]
Autonomous AI systems in the face of liability, regulations and costs.

NPJ Digit Med. 2023-10-6

[7]
A Review of Myoelectric Control for Prosthetic Hand Manipulation.

Biomimetics (Basel). 2023-7-24

[8]
Improved control of a prosthetic limb by surgically creating electro-neuromuscular constructs with implanted electrodes.

Sci Transl Med. 2023-7-12

[9]
Electrochemistry in a Two- or Three-Electrode Configuration to Understand Monopolar or Bipolar Configurations of Platinum Bionic Implants.

Micromachines (Basel). 2023-3-24

[10]
Long-term upper-extremity prosthetic control using regenerative peripheral nerve interfaces and implanted EMG electrodes.

J Neural Eng. 2023-4-25

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