斋月禁食对糖尿病患者药物依从性的影响：来自印度尼西亚的证据。
Impact of Ramadan Fasting on Medication Adherence in Patients with Diabetes Mellitus: Evidence from Indonesia.
作者信息
Nita Yunita, Alfian Riza, Libriansyah Libriansyah, Yuda Ana, Erifiannisa Renata Diva, Putri Sonia Anggitha
机构信息
Department of Pharmacy Practice, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia.
Department of Pharmacy, Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin, Banjarmasin, Indonesia.
出版信息
Patient Prefer Adherence. 2025 May 15;19:1425-1431. doi: 10.2147/PPA.S526018. eCollection 2025.
BACKGROUND
Diabetes mellitus is a chronic disease that requires long-term drug use and medication compliance to achieve optimal disease control. Indonesia's population is predominantly muslim. Fasting during Ramadan presents unique challenges for patients with diabetes mellitus in maintaining medication adherence due to lifestyle changes, such as mealtimes and medication schedules.
OBJECTIVE
This study aimed to compare the medication adherence levels among diabetes mellitus patients in Indonesia who fast during the month of Ramadan with those in other regular months.
METHODS
A longitudinal study was conducted using a survey of patients with diabetes at the Central Naval Hospital (RSPAL) Dr. Ramelan Surabaya. Data were collected from February to March 2024 using the picture pill count method. Data were analyzed using the chi-square test to determine the differences in medication adherence between the groups recruited during Ramadan and the other months.
RESULTS
In both groups, there was a predominance of single-drug and two-drug combination therapies, with metformin being the most widely used drug. The level of adherence to treatment during Ramadan was significantly lower than that during the regular month (p=0.005). In total, 96.5% of patients showed high levels of compliance during the regular month compared to 89% during Ramadan.
CONCLUSION
The level of adherence to diabetes treatment among patients with diabetes mellitus during Ramadan was lower than during regular months.
背景
糖尿病是一种慢性病，需要长期用药且患者需遵守医嘱以实现最佳的疾病控制。印度尼西亚人口主要为穆斯林。斋月期间禁食因进餐时间和用药时间表等生活方式的改变，给糖尿病患者维持用药依从性带来了独特挑战。
目的
本研究旨在比较印度尼西亚斋月期间禁食的糖尿病患者与其他正常月份患者的用药依从性水平。
方法
在泗水市拉梅兰海军中央医院（RSPAL）对糖尿病患者进行调查，开展一项纵向研究。于2024年2月至3月使用图片药丸计数法收集数据。采用卡方检验分析数据，以确定斋月期间招募的组与其他月份组之间用药依从性的差异。
结果
两组中，单一药物和两药联合治疗占主导，二甲双胍是使用最广泛的药物。斋月期间的治疗依从性水平显著低于正常月份（p = 0.005）。总体而言，96.5%的患者在正常月份表现出高依从性，而斋月期间这一比例为89%。
结论
糖尿病患者在斋月期间的糖尿病治疗依从性水平低于正常月份。
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