Xu Haopeng, Tang Yilin, Mao Wenjing, Wu Liu, Zhou Yiqing, Deng Juan, Tang Wentao, Xiao Xinfang, Xia Yi, Wang Yan
State Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, 400016, China.
Regen Ther. 2025 Apr 30;29:484-492. doi: 10.1016/j.reth.2025.04.012. eCollection 2025 Jun.
Bone marrow mesenchymal stem cells (BMSCs) are pluripotent and self-renewing, exerting a crucial role in the domain of regenerative medicine. Nevertheless, BMSCs encounter challenges such as low cell viability and inadequate homing during transplantation, thereby restricting their therapeutic efficacy. Hence, current research is concentrated on identifying optimal retention approaches following BMSCs transplantation to enhance its effectiveness. Low-intensity ultrasound (LIUS) has been verified as an efficacious method to enhance the performance of BMSCs. We established a skin trauma model and assessed the therapeutic effect of LIUS-preconditioned BMSCs. The results demonstrated that pretreatment with LIUS could expedite wound healing and effectively diminish scar formation post-transplantation by promoting proliferation capacity, reinforcing anti-apoptotic attributes, improving homing ability, and significantly enhancing the transplantation effect of BMSCs. These discoveries imply that LIUS might constitute a promising strategy for attaining optimal retention after stem cell transplantation in regenerative medicine and wound repair therapy.
骨髓间充质干细胞（BMSCs）具有多能性和自我更新能力，在再生医学领域发挥着关键作用。然而，BMSCs在移植过程中面临细胞活力低和归巢不足等挑战，从而限制了它们的治疗效果。因此，目前的研究集中在确定BMSCs移植后的最佳保留方法，以提高其有效性。低强度超声（LIUS）已被证实是一种提高BMSCs性能的有效方法。我们建立了皮肤创伤模型，并评估了经LIUS预处理的BMSCs的治疗效果。结果表明，LIUS预处理可通过促进增殖能力、增强抗凋亡特性、提高归巢能力以及显著增强BMSCs的移植效果，加速伤口愈合并有效减少移植后的瘢痕形成。这些发现表明，LIUS可能是再生医学和伤口修复治疗中干细胞移植后实现最佳保留的一种有前景的策略。
