Baghel Anamika, Nigam Aruna, Gupta Nidhi
Department of Obstetrics and Gynecology, Hamdard Institute of Medical Sciences and Research, Jamia Hamdard, New Delhi, India.
J Obstet Gynaecol India. 2025 Apr;75(Suppl 1):333-339. doi: 10.1007/s13224-024-01992-8. Epub 2024 Jun 27.
To study glycemic variability (GV) and 24-h ambulatory glucose profile (AGP) in gestational diabetes mellitus (GDM) patients who were apparently controlled on drugs and their correlation with fetomaternal outcomes.
In this cross-sectional observational study, 40 gestational diabetic pregnancies on pharmacotherapy were recruited. Flash glucose monitor was used to record AGP between 32 and 36 weeks of gestation. A total of 600 patient days with 58,600 glucose values were analyzed.
Variables of GV: Mean amplitude of glycemic excursion ( = 0.001), standard deviation ( = 0.001), Continuous Overall Net Glycemic Action ( = 0.002) and High Blood Glucose Index ( = 0.001) were significantly high in GDM group when compared to normoglycemic patients and these were well correlated with poor fetomaternal outcome in this group. Time in range was also significantly altered in GDM group. ( < 0.001).
High GV and time in range are the important parameters which get altered in GDM pregnancies despite apparent control of blood glucose, and this can be a reason of adverse fetomaternal outcomes in these pregnancies.
研究在药物治疗下血糖看似得到控制的妊娠期糖尿病（GDM）患者的血糖变异性（GV）和24小时动态血糖谱（AGP），以及它们与母婴结局的相关性。
在这项横断面观察性研究中，招募了40例接受药物治疗的妊娠期糖尿病孕妇。使用动态血糖监测仪记录妊娠32至36周期间的AGP。共分析了600个患者日的58,600个血糖值。
GV变量：与血糖正常的患者相比，GDM组的血糖波动平均幅度（=0.001）、标准差（=0.001）、连续总体净血糖作用（=0.002）和高血糖指数（=0.001）显著更高，且这些指标与该组不良母婴结局密切相关。GDM组的血糖达标时间也有显著改变（<0.001）。
高GV和血糖达标时间是GDM妊娠中尽管血糖看似得到控制但仍发生改变的重要参数，这可能是这些妊娠中母婴不良结局的一个原因。
