Shukla Amlin, Ashraf Ganie Mohd, Sudharsan V, Arora Taruna, Rather Khalid Ul Islam, Chowdhury Subhankar, Suri Vanita, Joshi Beena, Bhattacharya Prasanta Kumar, Agrawal Sarita, Malhotra Neena, Sahay Rakesh, Jabbar Puthiyaveettil Khadar, Nair Abilash, Rozati Roya, Rashid Haroon, Wani Imtiyaz Ahmad, Maan Pratibha, Gautam Rohit
ICMR, Ramalingaswami Bhawan, Ansari Nagar, P.O. Box No. 4911, New Delhi, 110029 India.
Department of Endocrinology, Sher-I-Kashmir Institute of Medical Sciences, Srinagar, India.
J Obstet Gynaecol India. 2025 Apr;75(Suppl 1):70-77. doi: 10.1007/s13224-024-01994-6. Epub 2024 Jul 29.
Age at menarche is believed to be an important indicator of reproductive maturity in women and hence a mirror to the health status of the population. Polycystic ovarian syndrome (PCOS) is a common endocrine disorder that affects reproductive-age women. Girls with early menarche are more likely to develop PCOS-like features. The paper explores the associations of age at menarche with PCOS and other health outcomes especially in relation to the presence of PCOS, related reproductive and metabolic abnormalities.
This is a secondary analysis of data collected from analytical cross-sectional study, conducted at ten centres in the six zones of India, as a part of ICMR task force project. The participants ( = 10,109) who were enrolled for the study comprised of women aged 18-40 years.
The mean age of menarche was 13.15 ± SD. The age of menarche reduced at a rate of 0.018 ( value = years per unit increase in years). Those with late onset of menarche had 1.45 times more odds of developing PCOS when compared to those who had a normal age of onset of menarche. What about early onset of menarche?
A receding age at menarche among younger girls as compared to older women which may be due to a trend of reducing age at menstrual onset. While, there was an association of PCOS diagnosis with extremes of age at menarche, more marked in case of late onset of menarche, more studies are necessary to establish the relationship.
初潮年龄被认为是女性生殖成熟的重要指标，因此也是人口健康状况的一面镜子。多囊卵巢综合征（PCOS）是一种影响育龄女性的常见内分泌疾病。初潮早的女孩更有可能出现类似PCOS的特征。本文探讨初潮年龄与PCOS及其他健康结局的关联，尤其是与PCOS的存在、相关生殖和代谢异常的关系。
这是对一项分析性横断面研究收集的数据进行的二次分析，该研究作为印度医学研究理事会（ICMR）特别工作组项目的一部分，在印度六个地区的十个中心开展。参与该研究的10109名参与者为年龄在18至4岁之间的女性。
初潮的平均年龄为13.15±标准差。初潮年龄以每年0.018的速率降低（值=每增加一岁的年数）。与初潮年龄正常的女性相比，初潮晚的女性患PCOS的几率高出1.45倍。那么初潮早的情况呢？
与年长女性相比，年轻女孩的初潮年龄在下降，这可能是由于月经初潮年龄降低的趋势。虽然PCOS诊断与初潮年龄的极端情况有关，在初潮晚的情况下更为明显，但需要更多研究来确定这种关系。
