Ishimaru K, Nakagawara A, Zaizen Y, Ikeda K
Z Kinderchir. 1985 Feb;40(1):36-9. doi: 10.1055/s-2008-1059708.
The efficacy of the combined treatment of cisplatin and radiation therapy for mouse C1 300 neuroblastoma was studied. Intraperitoneal cisplatin injections and/or radiation were given from 7 to 21 days after inoculation of the tumor cells into the thigh region of A/Jax mice. The combination of 15 Gy radiation and 6 mg/kg cisplatin had an additive effect on both tumour growth delay and survival rate, while that of 30 Gy radiation and 6 mg/kg cisplatin had a synergistic effect. The efficacy of the combined therapy was dependent on the dose of radiation but not on the dose of cisplatin. The normal skin of the mouse was damaged in the similar pattern with both treatments. Thus, cisplatin has a potent radiosensitising effect in the treatment of mouse neuroblastoma.
研究了顺铂与放射治疗联合治疗小鼠C1 300神经母细胞瘤的疗效。在将肿瘤细胞接种到A/Jax小鼠大腿区域后的7至21天，给予腹腔注射顺铂和/或进行放射治疗。15 Gy放射剂量与6 mg/kg顺铂联合使用对肿瘤生长延迟和存活率均有相加作用，而30 Gy放射剂量与6 mg/kg顺铂联合使用则有协同作用。联合治疗的疗效取决于放射剂量，而不取决于顺铂剂量。两种治疗方式对小鼠正常皮肤的损伤模式相似。因此，顺铂在小鼠神经母细胞瘤治疗中具有强大的放射增敏作用。
