Komatsu K, Nakamura W, Kageyama K
C R Seances Soc Biol Fil. 1985;179(4):554-7.
The possibility that an irradiation with small doses of gamma rays given shortly before might enhance the cure effect of cis-diammine-dichloroplatinum (II) (CDDP) was tested in tumor bearing mice. Tumor cells of FMA3, a cloned cell line of murine mastocytoma, were transplanted in the muscle of a hind leg in one experiment and in the abdominal cavity in another experiment. In both cases, a single injection of CDDP at 4 mg/kg was effective to lengthen the mean survival time of mice. gamma rays at the dose of 1, 2 and 4 Gy given 3 hours before did not modify the effect of CDDP.
在荷瘤小鼠中测试了在短时间前给予小剂量γ射线照射可能增强顺二氯二氨铂（II）（CDDP）治疗效果的可能性。在一项实验中，将小鼠肥大细胞瘤的克隆细胞系FMA3的肿瘤细胞移植到后腿肌肉中，在另一项实验中移植到腹腔中。在这两种情况下，以4mg/kg的剂量单次注射CDDP可有效延长小鼠的平均存活时间。在给药前3小时给予1、2和4Gy剂量的γ射线并未改变CDDP的效果。
