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剖宫产术中布比卡因注射液直接注入腹直肌鞘作为一种有效镇痛方法的评估

Evaluation of Bupivacaine Injection Instillation Directly in the Rectus Sheath in LSCS Cases as an Effective Analgesia Method.

作者信息

Dubey Tripti, Yadav Shivangi Dubey, Kundawar Amey

机构信息

Apollo Hospital, Navi Mumbai, India.

Seth G.S Medical College, KEM Hospital, Mumbai, Maharashtra India.

出版信息

J Obstet Gynaecol India. 2025 Apr;75(Suppl 1):250-255. doi: 10.1007/s13224-024-01947-z. Epub 2024 Mar 28.

DOI:10.1007/s13224-024-01947-z
PMID:40390964
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12085519/
Abstract

BACKGROUND

An ideal post-cesarean section analgesic plan should aim for high-quality pain relief with minimal side effects, no risk of transfer through breast milk, and a faster return to normal maternal functioning. This study is aimed to assess the efficacy of analgesic action of direct infiltration of bupivacaine in patients undergoing LSCS.

METHODS

This was a retrospective cross-sectional record analysis, assessing the medical records of 49 patients who were included from the medical records department of Apollo hospital, Belapur, Navi Mumbai.

RESULTS

49% patients did not require analgesics in the first 12 h postoperatively. The mean time of first demand of analgesia was 3.44 h (SD = 5.45). 61.2% patients were mobilized in 14 h or less postoperatively. In 69.4% patients, oral intake was initiated within 3 h of the surgery. 73.5% patient's initiated breastfeeding immediately after the surgery. At 4 h after surgery, the pain score was an average of 0.49 (SD = 0.79). 79.6% patients did not report postoperative nausea and vomiting. No patients reported wound infection or dehiscence post-surgery.

CONCLUSION

Bupivacaine infiltration post-cesarean section is a safe, effective and convenient method since it requires minimal available resources and no additional skills or supervision from medical experts. Hence, it is more suitable, especially in developing countries and rural/peripheral hospitals/maternity centers where the availability of equipment like USG machine may be difficult, making cheap, accessible yet effective analgesic options the need of the hour in post-LSCS patients.

摘要

背景

理想的剖宫产术后镇痛方案应旨在实现高质量的疼痛缓解,副作用最小,无通过母乳传递的风险,并能更快恢复产妇正常功能。本研究旨在评估布比卡因直接浸润对接受低位剖宫产术患者的镇痛效果。

方法

这是一项回顾性横断面记录分析,评估了从孟买新市镇贝拉布尔阿波罗医院病历科纳入的49例患者的病历。

结果

49%的患者术后12小时内不需要镇痛。首次需要镇痛的平均时间为3.44小时(标准差=5.45)。61.2%的患者术后14小时或更短时间内可活动。69.4%的患者在手术后3小时内开始经口进食。73.5%的患者术后立即开始母乳喂养。术后4小时,疼痛评分平均为0.49(标准差=0.79)。79.6%的患者未报告术后恶心和呕吐。没有患者报告术后伤口感染或裂开。

结论

剖宫产术后布比卡因浸润是一种安全、有效且方便的方法,因为它所需的可用资源最少,不需要医学专家的额外技能或监督。因此,它更合适,尤其是在发展中国家以及农村/周边医院/产科中心,那里可能难以获得超声机等设备,使得廉价、易获取且有效的镇痛选择成为低位剖宫产术后患者当前的需求。

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Evaluation of Bupivacaine Injection Instillation Directly in the Rectus Sheath in LSCS Cases as an Effective Analgesia Method.剖宫产术中布比卡因注射液直接注入腹直肌鞘作为一种有效镇痛方法的评估
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本文引用的文献

1
Efficacy of Single Wound Infiltration With Bupivacaine and Adrenaline During Cesarean Delivery for Reduction of Postoperative Pain: A Randomized Clinical Trial.剖宫产术中单次浸润布比卡因和肾上腺素减轻术后疼痛的效果:一项随机临床试验。
JAMA Netw Open. 2022 Nov 1;5(11):e2242203. doi: 10.1001/jamanetworkopen.2022.42203.
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Analgesia for Caesarean section.剖宫产镇痛
BJA Educ. 2022 May;22(5):197-203. doi: 10.1016/j.bjae.2021.12.008. Epub 2022 Mar 8.
3
Wound Infusion of 0.35% Levobupivacaine Reduces Mechanical Secondary Hyperalgesia and Opioid Consumption After Cesarean Delivery: A Prospective, Randomized, Triple-Blind, Placebo-Controlled Trial.剖宫产术后伤口注入0.35%左旋布比卡因可减轻机械性继发性痛觉过敏并减少阿片类药物用量:一项前瞻性、随机、三盲、安慰剂对照试验
Anesth Analg. 2022 Apr 1;134(4):791-801. doi: 10.1213/ANE.0000000000005917.
4
The Efficacy and Safety of Local Anesthetic Techniques for Postoperative Analgesia After Cesarean Section: A Bayesian Network Meta-Analysis of Randomized Controlled Trials.剖宫产术后局部麻醉技术用于术后镇痛的有效性和安全性:一项随机对照试验的贝叶斯网络荟萃分析
J Pain Res. 2021 Jun 2;14:1559-1572. doi: 10.2147/JPR.S313972. eCollection 2021.
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Transversus abdominis plane block versus local anaesthetic wound infiltration for analgesia after caesarean section: A systematic review and meta-analysis with trial sequential analysis.腹横肌平面阻滞与局部麻醉浸润用于剖宫产术后镇痛的效果比较:一项系统评价和荟萃分析,包含试验序贯分析。
Eur J Anaesthesiol. 2022 Mar 1;39(3):244-251. doi: 10.1097/EJA.0000000000001552.
6
Effectiveness of wound site infiltration for parturients undergoing elective cesarean section in an Ethiopian hospital: A prospective cohort study.埃塞俄比亚一家医院中择期剖宫产产妇伤口部位浸润麻醉的效果:一项前瞻性队列研究
Ann Med Surg (Lond). 2021 Mar 29;64:102255. doi: 10.1016/j.amsu.2021.102255. eCollection 2021 Apr.
7
Regional Anesthesia Abdominal Blocks and Local Infiltration After Cesarean Delivery: Review of Current Evidence.剖宫产术后腹部区域阻滞和局部浸润:当前证据回顾。
Curr Pain Headache Rep. 2021 Mar 24;25(5):28. doi: 10.1007/s11916-021-00945-4.
8
Enhanced Recovery After Cesarean: Current and Emerging Trends.剖宫产术后加速康复:现状与新趋势
Curr Anesthesiol Rep. 2021;11(2):136-144. doi: 10.1007/s40140-021-00442-9. Epub 2021 Mar 2.
9
PROSPECT guideline for elective caesarean section: updated systematic review and procedure-specific postoperative pain management recommendations.择期剖宫产 PROSPECT 指南:更新的系统评价和特定手术术后疼痛管理建议。
Anaesthesia. 2021 May;76(5):665-680. doi: 10.1111/anae.15339. Epub 2020 Dec 28.
10
Bupivacaine Pharmacokinetics and Breast Milk Excretion of Liposomal Bupivacaine Administered After Cesarean Birth.布比卡因的药代动力学和剖宫产术后给予脂质体布比卡因的母乳排泄。
Obstet Gynecol. 2020 Jul;136(1):70-76. doi: 10.1097/AOG.0000000000003886.