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ST段抬高型心肌梗死溶栓治疗后发生肺泡出血：两例罕见病例报告及文献综述

Alveolar hemorrhage following thrombolysis in STEMI: Two rare case reports and review of the literature.

作者信息

Hamissou Ibrahim Oumarou

机构信息

Department of Cardiology, University Mohammed-V of Rabat, Morocco.

出版信息

Glob Cardiol Sci Pract. 2025 Feb 28;2025(1):e202516. doi: 10.21542/gcsp.2025.16.

DOI:10.21542/gcsp.2025.16
PMID:40390989
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12085929/
Abstract

This retrospective study, conducted in the Cardiology-B department of Ibn Sina Hospital, Rabat, analyzed 44 patients and describes two rare cases of alveolar hemorrhage occurring after thrombolysis in patients diagnosed with ST-segment elevation myocardial infarction (STEMI). While contributing to the development of a larger registry for this rare condition, these two unique cases from our institution are noteworthy in their own right. We also surveyed the current literature to identify risk factors for alveolar hemorrhage following thrombolysis in STEMI patients to understand the underlying pathophysiological mechanisms and propose an optimal management strategy.

摘要

这项回顾性研究在拉巴特伊本·西那医院心脏病学B科进行，分析了44例患者，并描述了2例被诊断为ST段抬高型心肌梗死（STEMI）的患者在溶栓后发生肺泡出血的罕见病例。在为这种罕见疾病建立更大的登记系统做出贡献的同时，我们机构的这两个独特病例本身就值得关注。我们还查阅了当前文献，以确定STEMI患者溶栓后肺泡出血的危险因素，了解潜在的病理生理机制，并提出最佳管理策略。

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本文引用的文献

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Fibrinolysis: an illustrated review.纤维蛋白溶解：图文并茂的综述。
Res Pract Thromb Haemost. 2023 Feb 17;7(2):100081. doi: 10.1016/j.rpth.2023.100081. eCollection 2023 Feb.
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Post thrombolytic alveolar hemorrhage: a case report.溶栓后肺泡出血：一例报告
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[Evaluating the performance of Tunisian regional hospitals. Study Protocol of management delays of ST elevation myocardial infarction].[评估突尼斯地区医院的绩效。ST段抬高型心肌梗死管理延误的研究方案]
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Alveolar Hemorrhage Following Thrombolytic Therapy for Acute Myocardial Infarction: Two Case Reports and Literature Review.急性心肌梗死溶栓治疗后肺泡出血：两例报告及文献综述
Open Access Emerg Med. 2021 Aug 27;13:399-405. doi: 10.2147/OAEM.S324366. eCollection 2021.
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Pulmonary haemorrhage following thrombolysis with streptokinase in myocardial infarction.心肌梗死患者使用链激酶溶栓后发生肺出血。
BMJ Case Rep. 2020 Jan 23;13(1):e232308. doi: 10.1136/bcr-2019-232308.
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2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC).2017年欧洲心脏病学会（ESC）ST段抬高型急性心肌梗死患者管理指南：欧洲心脏病学会（ESC）ST段抬高型急性心肌梗死患者管理工作组
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Pulmonary alveolar hemorrhage following thrombolytic therapy.溶栓治疗后肺泡出血
Int Med Case Rep J. 2017 Apr 4;10:123-125. doi: 10.2147/IMCRJ.S129087. eCollection 2017.
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Absolute and Relative Contraindications to IV rt-PA for Acute Ischemic Stroke.急性缺血性卒中静脉注射重组组织型纤溶酶原激活剂的绝对和相对禁忌证。
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