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用顺式二氯二氨铂(II)治疗的患者中铂的胆汁排泄情况。

Biliary excretion of platinum in a patient treated with cis-dichlorodiammineplatinum (II).

作者信息

Shelley M D, Fish R G, Adams M

出版信息

Antimicrob Agents Chemother. 1985 Feb;27(2):275-6. doi: 10.1128/AAC.27.2.275.

DOI:10.1128/AAC.27.2.275
PMID:4039121
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC176254/
Abstract

Biliary excretion of platinum was measured in a patient receiving an intravenous infusion of cis-dichlorodiammineplatinum (II). Over a 3-day period, less than 1% of the administered platinum was detected in the bile, and 47% appeared in the urine, indicating that biliary excretion is a minor route of elimination.

摘要

对一名接受静脉输注顺二氯二氨铂(II)的患者的铂胆汁排泄情况进行了测定。在3天的时间里,胆汁中检测到的铂不到给药量的1%,而47%出现在尿液中,这表明胆汁排泄是一条次要的消除途径。

相似文献

1
Biliary excretion of platinum in a patient treated with cis-dichlorodiammineplatinum (II).用顺式二氯二氨铂(II)治疗的患者中铂的胆汁排泄情况。
Antimicrob Agents Chemother. 1985 Feb;27(2):275-6. doi: 10.1128/AAC.27.2.275.
2
Platinum concentrations in bile and plasma following rapid and 6-hour infusions of cis-dichlorodiammineplatinum(II).快速输注和顺式二氯二氨铂(II)6小时输注后胆汁和血浆中的铂浓度。
Cancer Treat Rep. 1979 Nov-Dec;63(11-12):2023-5.
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Cancer Treat Rep. 1979 Jun;63(6):951-60.
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Pharmacokinetics of anticancer drugs in children.儿童抗癌药物的药代动力学
Clin Pharmacokinet. 1987 Mar;12(3):168-213. doi: 10.2165/00003088-198712030-00002.

本文引用的文献

1
Total body clearance and platinum accumulation in patients treated with cis-dichlorodiammine platinum (II).接受顺二氯二氨铂(II)治疗的患者的全身清除率和铂蓄积情况。
Ther Drug Monit. 1984;6(2):251-2. doi: 10.1097/00007691-198406000-00021.
2
Pharmacokinetics of free and total platinum species after short-term infusion of cisplatin.短期输注顺铂后游离铂和总铂物种的药代动力学。
Cancer Treat Rep. 1984 Mar;68(3):505-13.
3
Pharmacokinetics and protein binding of cis-dichlorodiammine platinum (II) administered as a one hour or as a twenty hour infusion.
Cancer Chemother Pharmacol. 1980;5(1):21-6. doi: 10.1007/BF00578558.
4
Platinum concentrations in bile and plasma following rapid and 6-hour infusions of cis-dichlorodiammineplatinum(II).快速输注和顺式二氯二氨铂(II)6小时输注后胆汁和血浆中的铂浓度。
Cancer Treat Rep. 1979 Nov-Dec;63(11-12):2023-5.
5
Effect of a forced diuresis on the distribution and excretion (via urine and bile) of 195mplatinum when given as 195mplatinum cis-dichlorodiammineplatinum(II).
Cancer Treat Rep. 1979 Jun;63(6):951-60.
6
Biliary excretion of drugs in man.人体中药物的胆汁排泄。
Clin Pharmacokinet. 1979 Sep-Oct;4(5):368-79. doi: 10.2165/00003088-197904050-00003.