Dowe Brittany, Iheanyi-Okeahialam Chidinma, Washington Ariel, Bock Cathryn, Kinney Ten-Niah, Brown-Miller Voncile, West Judith Harper, Sims Cornelius, Chapman Rochelle, Marks Bertram, Schwartz Ann G, Thompson Hayley S
Karmanos Cancer Institute, School of Medicine, Wayne State University, Detroit, MI, USA.
School of Medicine, Wayne State University, Detroit, MI, USA.
Cancer Control. 2025 Jan-Dec;32:10732748251343247. doi: 10.1177/10732748251343247. Epub 2025 May 20.
IntroductionGenomic and genetic research are integral to precision medicine and contemporary cancer care. These approaches hold great promise for addressing longstanding racial cancer disparities and poor cancer outcomes observed in Black populations. However, in Black populations, there are several barriers to participating in genomic and genetic research. Faith-based organizations, specifically Black churches, offer a unique opportunity to both address these barriers and foster the environment for community engagement that can lead to greater awareness and interest in genomics, genetics, precision medicine, and cancer clinical trials.MethodsIn the present study, the study team partnered with metropolitan Detroit Black churches to develop and implement a pilot intervention to increase genetic and clinical trial literacy, as well as interest in cancer clinical trials, titled, "The Future of Medicine is Now". During the intervention, facilitators presented videos, produced by the project team and partners, that addressed precision medicine, familial risk, genetic risk assessment, and cancer clinical trials. Facilitators also responded to questions and led discussion throughout the program.ResultsIn total, 106 individuals consented to participate in research components of the program. The mean age of the participants was 46.5 (SD = 16.8) years; 73.6% (n = 48) identified as female, and 89.6% (n = 95) identified as Black. Attitudes related to clinical trials participation improved from pre- to post-education session; at pre-test 49.5% of participants agreed with the statement "I am likely to search for a clinical trial that I might be eligible for", as opposed to 67.0% at post-test. Improvements related to genetic literacy were also seen from pre- to post-test.ConclusionResults from this study suggest that collaborations with faith-based organizations are effective in building knowledge and interest in genomics, genetics, precision medicine, and research in Black communities. Future research should aim to incorporate community- and culturally-specific engagement strategies to increase participation in research.
引言
基因组和遗传学研究是精准医学及当代癌症治疗不可或缺的一部分。这些方法对于解决长期存在的种族癌症差异以及黑人人群中不良的癌症治疗结果具有巨大潜力。然而,在黑人人群中,参与基因组和遗传学研究存在若干障碍。基于信仰的组织,特别是黑人教会,提供了一个独特的机会,既能消除这些障碍,又能营造社区参与的环境,从而提高对基因组学、遗传学、精准医学和癌症临床试验的认识和兴趣。
方法
在本研究中,研究团队与底特律都会区的黑人教会合作,开展并实施了一项名为“医学的未来就在当下”的试点干预措施,以提高基因和临床试验知识水平,以及对癌症临床试验的兴趣。在干预过程中,主持人播放了由项目团队及合作伙伴制作的视频,内容涉及精准医学、家族风险、基因风险评估和癌症临床试验。主持人还回答问题,并在整个项目过程中引导讨论。
结果
共有106人同意参与该项目的研究部分。参与者的平均年龄为46.5岁(标准差 = 16.8);73.6%(n = 48)为女性,89.6%(n = 95)为黑人。与临床试验参与相关的态度在教育课程前后有所改善;在预测试中,49.5%的参与者同意“我可能会寻找一个我可能符合条件的临床试验”这一说法,而在测试后这一比例为67.0%。从预测试到测试后,基因知识水平也有提高。
结论
本研究结果表明,与基于信仰的组织合作对于在黑人社区建立对基因组学、遗传学、精准医学和研究的知识及兴趣是有效的。未来的研究应旨在纳入针对社区和文化的特定参与策略,以增加研究参与度。