Green Melissa A, Michaels Margo, Blakeney Natasha, Odulana Adebowale A, Isler Malika Roman, Richmond Alan, Long Debra G, Robinson William S, Taylor Yhenneko J, Corbie-Smith Giselle
NC TraCS Institute, University of North Carolina at Chapel Hill, 140 North Medical Drive, CB#7064, Chapel Hill, NC, 27599-7064, USA,
J Cancer Educ. 2015 Mar;30(1):158-66. doi: 10.1007/s13187-014-0764-1.
Cancer clinical trial (CCT) accrual and retention rates remain disproportionately low among African Americans. Awarenesss and access to trials are crucial facilitators of trial participation. Strategies developed within a community-based participatory framework (CBPR) are potential solutions to increase awareness and access to CCTs. In this study, we describe the pilot phase of three innovative community-centered modules to improve basic CCT knowledge, awareness of locations to access CCT information, and opportunities to participate in CCTs. Four community organizations completed Community Bridges to CCT training-of-the-trainer and recruited adult African American volunteers to participate in one of three CCT education modules: a workshop about CCTs, a role play describing one person's experience with CCTs, or a call and response session reviewing myths and facts about CCTs. Pre- and post-test surveys were collected and analyzed using McNemar agreement statistic to evaluate changes in knowledge and attitudes regarding trials. Trainers enrolled 125 participants in the call and response (n = 22), role play (n = 60), and workshop (n = 43) modules. Module participants were mostly African American, female, and with a mean age of 53 years. Comparison of pre- and post-test responses demonstrates favorable changes in awareness of CCTs and where to access CCTs across the sample. Analysis by module type indicates significant increases for participants in the call and response (p < 0.01) and role play modules (p < 0.001), but not the workshop module. Despite measures taken to increase the participation and retention rate of African Americans in clinical trials, little advancement has been made. Developing tailored community education modules on CCTs within the CBPR framework is a promising innovation to increase knowledge about CCTs and favorable attitudes about participation that are known precursors to trial enrollment.
在非裔美国人中，癌症临床试验（CCT）的入组率和留存率仍然低得不成比例。对试验的认知和参与途径是促进试验参与的关键因素。在基于社区的参与式框架（CBPR）内制定的策略是提高对CCT的认知和参与途径的潜在解决方案。在本研究中，我们描述了三个以社区为中心的创新模块的试点阶段，以提高对CCT基础知识的了解、获取CCT信息的地点的知晓度以及参与CCT的机会。四个社区组织完成了“通往CCT的社区桥梁”培训师培训，并招募成年非裔美国志愿者参加三个CCT教育模块之一：关于CCT的研讨会、描述一个人CCT经历的角色扮演，或回顾关于CCT的误解与事实的问答环节。收集并使用麦克尼马尔一致性统计量分析前后测试调查问卷，以评估关于试验的知识和态度的变化。培训师在问答（n = 22）、角色扮演（n = 60）和研讨会（n = 43）模块中招募了125名参与者。模块参与者大多是非裔美国人、女性，平均年龄为53岁。前后测试回答的比较表明，整个样本在对CCT的认知以及获取CCT的地点方面有积极变化。按模块类型分析表明，问答模块（p < 0.01）和角色扮演模块（p < 0.001）的参与者有显著增加，但研讨会模块没有。尽管采取了措施来提高非裔美国人参与临床试验的比例和留存率，但进展甚微。在CBPR框架内开发针对CCT的定制社区教育模块是一项有前途的创新，可增加对CCT的了解以及对参与的积极态度，而这些是已知的试验入组的先兆。
