Reiter M, Brandt W
Arzneimittelforschung. 1985;35(1A):408-14.
The effects of volatile oils of 22 plants from 11 different families and of some of their constituents on tracheal and ileal smooth muscles were investigated. The results were compared with the relaxant effects of catecholamines and phosphodiesterase inhibitors. All of the oils had relaxant effects on the tracheal smooth muscle, the most potent were angelica root, clove, elecampane root, basil and balm leaves oil. 16 oils inhibited the phasic contractions of the ileal myenteric plexus-longitudinal muscle preparation, the most potent were elecampane root, clove, thyme, balm leaves and angelica root oil. 2 oils (anise and fennel) increased the phasic contractions, and 4 oils (bitter orange, caraway, mace, pepper) produced a marked increase in resting force (i.e. contracture). In regard to the relaxant effects, most of the 16 oils were more potent on the ileal than on the tracheal muscle. However, a small group of 4 oils (angelica root, clove, basil, black caraway) had a higher relaxant effect on the tracheal than on the ileal muscle. This was also found to be the case with eugenol, eugenol acetate and cinnamic aldehyde as well as with isoprenaline and phosphodiesterase inhibitors.
研究了来自11个不同科的22种植物的挥发油及其某些成分对气管和回肠平滑肌的作用。将结果与儿茶酚胺和磷酸二酯酶抑制剂的舒张作用进行了比较。所有的油对气管平滑肌都有舒张作用，其中最有效的是当归根、丁香、土木香根、罗勒和香蜂草叶油。16种油抑制回肠肌间神经丛 - 纵肌标本的相性收缩，其中最有效的是土木香根、丁香、百里香、香蜂草叶和当归根油。2种油（茴芹和茴香）增加相性收缩，4种油（苦橙、葛缕子、肉豆蔻、胡椒）使静息力（即挛缩）显著增加。关于舒张作用，16种油中的大多数对回肠肌的作用比对气管肌的作用更强。然而，一小类4种油（当归根、丁香、罗勒、黑孜然）对气管肌的舒张作用比对回肠肌的作用更强。丁香酚、乙酸丁香酚酯、肉桂醛以及异丙肾上腺素和磷酸二酯酶抑制剂也被发现是这种情况。
