社区居住老年人中潜在不适当用药及合并症与生活质量的关系：伊朗的一项横断面研究

Potentially inappropriate medication use and comorbidity in association with quality of life in community-dwelling older people: a cross-sectional study in Iran.

作者信息

Shirdozham Maryam, Feizi Awat, Rahimi Majid

机构信息

Department of Health Education and Health Promotion, School of Health, Isfahan University of Medical Sciences, Isfahan, Iran.

Department of Epidemiology & Biostatistics, School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran.

出版信息

BMC Prim Care. 2025 May 20;26(1):175. doi: 10.1186/s12875-025-02882-2.

DOI:10.1186/s12875-025-02882-2

PMID:40394468

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12090554/

Abstract

BACKGROUND

Multimorbidity, polypharmacy, and potentially inappropriate medication use in older adults are prevalent and affect their quality of life. This study investigates the interrelationship between potentially inappropriate medication use, comorbidity, and quality of life among older adults in Iran.

METHODS

This cross-sectional study was conducted on 500 older adults in Isfahan City, Iran. The Beers Criteria for Potentially Inappropriate Medication Use in Older Adults, a health-related quality-of-life questionnaire for older adults, and the Charlson Comorbidity Index were used to gather data.

RESULTS

Our findings related to older adults living in the Isfahan community showed that the prevalence of PIM was 61.6%, and the most common drug category was painkillers. The average quality of life score was (0.86 ± 0.08), and the worst category was related to sleep status. The average score of the CCI was 3.63 ± 1.40, with the most frequent diseases being hyperlipidemia, hypertension, and diabetes. After adjusting for confounding variables, a negative relationship between CCI (B = -0.009 [SE = 0.0027], P < 0.001) and PIM (B = -0.03 [SE = 0.007], P < 0.001) with quality of life was observed.

CONCLUSION

Potentially inappropriate medication uses and comorbidities are high in our older population, and these variables are negatively associated with quality of life in this population. There are few family physicians trained in geriatrics in Iran. Policymakers should pay attention to these issues.

摘要

背景

老年人中的多种疾病共存、多种药物治疗以及潜在的不适当用药情况普遍存在，并影响他们的生活质量。本研究调查了伊朗老年人中潜在的不适当用药、合并症与生活质量之间的相互关系。

方法

本横断面研究对伊朗伊斯法罕市的500名老年人进行。采用老年人潜在不适当用药的Beers标准、一份针对老年人的健康相关生活质量问卷以及Charlson合并症指数来收集数据。

结果

我们关于居住在伊斯法罕社区的老年人的研究结果表明，潜在不适当用药的患病率为61.6%，最常见的药物类别是止痛药。生活质量平均得分为（0.86±0.08），最差的类别与睡眠状况有关。Charlson合并症指数的平均得分为3.63±1.40，最常见的疾病是高脂血症、高血压和糖尿病。在对混杂变量进行调整后，观察到合并症指数（B = -0.009 [标准误 = 0.0027]，P < 0.001）和潜在不适当用药（B = -0.03 [标准误 = 0.007]，P < 0.001）与生活质量之间呈负相关。