Zare Forouzan, Ameri Hosein, Madadizadeh Farzan, Reza Aghaei Mohammad
Department of Health Technology Assessment, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Department of Epidemiology and Biostatistics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
SAGE Open Med. 2020 Oct 26;8:2050312120965314. doi: 10.1177/2050312120965314. eCollection 2020.
Assessing the health-related quality of life in patients with type 2 diabetes mellitus is important for evaluation of treatment outcome. The purpose of this study was to evaluate the health-related quality of life in type 2 diabetes mellitus patients and its related factors in Yazd.
Data were gathered by using the EuroQoL-five-dimension-5 level instrument as well as using medical records of 734 outpatients with type 2 diabetes mellitus who were referred to the largest governmental diabetes center in South of Iran, Yazd province. When appropriate, the Kruskal-Wallis test or the Wilcoxon test was used to test the difference in the health-related quality-of-life scores in each factor. Finally, the adjusted limited dependent variable mixture model was developed to investigate factors associated with health-related quality-of-life scores.
The mean and median of the EuroQoL-five-dimension-5 level index values of 717 patients who completed the questionnaires were 0.75 ± 0.006 and 0.72 ± 0.20, respectively, and those of the Visual Analogue Scale scores were 69.25 ± 0.63 and 75 ± 30, respectively. The mean scores for health-related quality of life were significantly higher for employed, educated, single, and male patients, as well as patients without comorbidities, diabetes-related complications, and hemoglobin A1c level >7%. Adjusted limited dependent variable mixture model showed that gender, age, marital status, and diabetes-related complications are significant independent predictors of EuroQoL-five-dimension-5 level index value.
The mean scores for health-related quality of life in patients with type 2 diabetes mellitus were moderate in this study, and this finding is consistent with health-related quality-of-life scores reported in other studies conducted in the Middle East region. Therefore, health-related quality of life should be the most important consideration in the management of patients. In parallel, some factors, especially gender, should be considered to improve health-related quality of life.
评估2型糖尿病患者的健康相关生活质量对于评估治疗效果很重要。本研究的目的是评估亚兹德地区2型糖尿病患者的健康相关生活质量及其相关因素。
使用欧洲五维健康量表（EuroQoL-five-dimension-5 level instrument）收集数据，并使用734名2型糖尿病门诊患者的病历，这些患者被转诊至伊朗南部最大的政府糖尿病中心——亚兹德省的糖尿病中心。在适当情况下，使用Kruskal-Wallis检验或Wilcoxon检验来检验每个因素中健康相关生活质量得分的差异。最后，建立调整后的有限因变量混合模型来研究与健康相关生活质量得分相关的因素。
完成问卷的717名患者的欧洲五维健康量表指数值的平均值和中位数分别为0.75±0.006和0.72±0.20，视觉模拟量表得分的平均值和中位数分别为69.25±0.63和75±30。就业、受过教育、单身和男性患者，以及没有合并症、糖尿病相关并发症且糖化血红蛋白水平>7%的患者，其健康相关生活质量的平均得分显著更高。调整后的有限因变量混合模型显示，性别、年龄、婚姻状况和糖尿病相关并发症是欧洲五维健康量表指数值的显著独立预测因素。
本研究中2型糖尿病患者的健康相关生活质量平均得分中等偏高，这一发现与中东地区其他研究报告的健康相关生活质量得分一致。因此，健康相关生活质量应是患者管理中最重要的考虑因素。同时，应考虑一些因素，特别是性别，以提高健康相关生活质量。
