Wang Chao, Xu Haotai, Wang Lei, Huang Sidan, Pan Bingcheng, Pan Hui, Jia Haisheng, Tang Shujie
School of Traditional Chinese Medicine, Jinan University, Guangzhou, China.
Zhongshan Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Traditional Chinese Medicine, Zhongshan, China.
Front Med (Lausanne). 2025 May 6;12:1573729. doi: 10.3389/fmed.2025.1573729. eCollection 2025.
This study aimed to investigate the association between Muscle Quality Index (MQI) and arthritis using data from the National Health and Nutrition Examination Survey (NHANES) 2011-2014.
A cross-sectional analysis was conducted using data from 4,558 participants aged 20-60 years. MQI was calculated using handgrip strength and appendicular skeletal muscle mass obtained through Dual-energy X-ray Absorptiometry (DXA) scans. Arthritis status was determined based on self-reported physician diagnoses. Multivariable logistic regression models were applied to examine the relationship between MQI and arthritis, adjusting for potential confounders, including demographic, socioeconomic, and lifestyle factors. Subgroup and sensitivity analyses were performed to evaluate heterogeneity.
Higher MQI was significantly associated with a lower risk of arthritis (adjusted OR = 0.73, 95% CI: 0.61-0.88, = 0.001). Subgroup analyses revealed stronger associations in participants aged 30-40 years (OR = 0.47, 95% CI: 0.31-0.71, < 0.001), females (OR = 0.68, 95% CI: 0.54-0.87, = 0.002), and non-hispanic black people individuals (OR = 0.62, 95% CI: 0.43-0.89, < 0.01). Sensitivity analysis confirmed a dose-response relationship, with participants in the highest MQI quartile having significantly lower odds of arthritis compared to the lowest quartile (adjusted OR = 0.69, 95% CI: 0.50-0.96, = 0.027).
MQI is inversely associated with arthritis prevalence, suggesting that maintaining muscle quality may be a critical factor in arthritis prevention. These findings highlight the importance of muscle health in public health strategies for arthritis management.
本研究旨在利用2011 - 2014年美国国家健康与营养检查调查（NHANES）的数据，调查肌肉质量指数（MQI）与关节炎之间的关联。
对4558名年龄在20 - 60岁的参与者的数据进行横断面分析。MQI通过握力和通过双能X线吸收法（DXA）扫描获得的四肢骨骼肌质量来计算。关节炎状态根据自我报告的医生诊断来确定。应用多变量逻辑回归模型来检验MQI与关节炎之间的关系，并对潜在的混杂因素进行调整，包括人口统计学、社会经济和生活方式因素。进行亚组分析和敏感性分析以评估异质性。
较高的MQI与较低的关节炎风险显著相关（调整后的比值比=0.73，95%置信区间：0.61 - 0.88，P = 0.001）。亚组分析显示，在30 - 40岁的参与者（比值比=0.47，95%置信区间：0.31 - 0.71，P < 0.001）、女性（比值比=0.68，95%置信区间：0.54 - 0.87，P = 0.002）和非西班牙裔黑人个体（比值比=0.62，95%置信区间：0.43 - 0.89，P < 0.01）中，关联更强。敏感性分析证实了剂量反应关系，与最低四分位数的参与者相比，最高MQI四分位数的参与者患关节炎的几率显著更低（调整后的比值比=0.69，95%置信区间：0.50 - 0.96，P = 0.027）。
MQI与关节炎患病率呈负相关，这表明维持肌肉质量可能是预防关节炎的关键因素。这些发现凸显了肌肉健康在关节炎管理公共卫生策略中的重要性。
