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肠道微生物群:使用中药及其活性成分预防和治疗失眠的新靶点。

Gut microbiota: a new target for the prevention and treatment of insomnia using Chinese herbal medicines and their active components.

作者信息

Wu Changmei, Dou Jinjin, Song Xiaoxue, Yang Fang, Liu Xuan, Song Weipeng, Zhang Xiwu

机构信息

Graduate School, Heilongjiang University of Chinese Medicine, Harbin, China.

The Four Hospital of Heilongjiang University of Chinese Medicine, Heilongjiang University of Chinese Medicine, Harbin, China.

出版信息

Front Pharmacol. 2025 May 6;16:1572007. doi: 10.3389/fphar.2025.1572007. eCollection 2025.

Abstract

The emergence of the microbiota-gut-brain axis has opened new avenues for improving sleep quality. Recent studies have revealed a close relationship between insomnia and the gut microbiome. Chinese herbal medicines and their active components can alter the relative abundance of sleep-related gut microbiota by reversing dysbiosis in the gut microbiome. Improving sleep quality through the regulation of the gut microbiota using herbal medicine and its active components has become a highly promising therapeutic strategy. This article elucidates how the gut microbiota modulates sleep quality via the intricate communication network of the gut-brain axis. It also reviews the latest research on utilizing herbal medicine and its active components to regulate the gut microbiota for enhancing sleep quality. Additionally, it provides insights into the potential of herbal medicine and its active components in improving sleep quality through the modulation of the gut microbiota.

摘要

微生物群-肠道-脑轴的出现为改善睡眠质量开辟了新途径。最近的研究揭示了失眠与肠道微生物群之间的密切关系。中药及其活性成分可通过逆转肠道微生物群的失调来改变与睡眠相关的肠道微生物群的相对丰度。利用草药及其活性成分通过调节肠道微生物群来改善睡眠质量已成为一种极具前景的治疗策略。本文阐明了肠道微生物群如何通过复杂的肠-脑轴通讯网络调节睡眠质量。它还综述了利用草药及其活性成分调节肠道微生物群以提高睡眠质量的最新研究。此外,它还深入探讨了草药及其活性成分通过调节肠道微生物群改善睡眠质量的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b1ef/12088967/d527168103a3/fphar-16-1572007-g001.jpg

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