Xu Jiake
henzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
School of Biomedical Sciences, The University of Western Australia, Perth, Western Australia, Australia.
Mechanobiol Med. 2023 Jul 5;1(1):100008. doi: 10.1016/j.mbm.2023.100008. eCollection 2023 Sep.
Mechanotransduction, the transfer of mechanical stimuli into various biological signals, is a vital biological process in multiple organ systems. The osteoclast (OC) plays a vital role in bone metabolism and repair. The role of mechanotransduction in osteoclasts and other bone cells is emerging. This commentary highlights a recent research report on a novel strategy for the precise regulation of OC formation via modulating matrix stiffness. Modulation of the mechanotransduction pathways in the skeletal system will pave the way for the development of a matrix stiffness-based strategy for bone tissue regeneration.
机械转导，即将机械刺激转化为各种生物信号的过程，是多个器官系统中至关重要的生物学过程。破骨细胞（OC）在骨代谢和修复中起着至关重要的作用。机械转导在破骨细胞和其他骨细胞中的作用正在逐渐显现。本评论重点介绍了一项关于通过调节基质硬度精确调控破骨细胞形成的新策略的最新研究报告。调节骨骼系统中的机械转导途径将为基于基质硬度的骨组织再生策略的开发铺平道路。
