苯环利定给药对大鼠行为及脑内神经降压素样免疫反应性的影响。

Effects of phencyclidine administration on behavior and brain neurotensin-like immunoreactivity in rats.

作者信息

Wachi M, Okuda M, Togashi S, Fuwano S, Miyashita O

出版信息

Brain Res. 1985 May 6;333(2):393-6. doi: 10.1016/0006-8993(85)91601-4.

Abstract

The effects of acute and chronic phencyclidine (PCP) administration on neurotensin-like immunoreactivity (NTLI) were investigated in discrete regions of rat brain. Both acute and chronic administration of PCP induced high locomotor activity, stereotypy and ataxia. On PCP administration, NTLI decreased significantly in the frontal cortex (Fc) alone. These results suggest that the decrease in NTLI in Fc is related to the behavioral abnormalities produced by PCP.

摘要

研究了急性和慢性给予苯环己哌啶（PCP）对大鼠脑离散区域中神经降压素样免疫反应性（NTLI）的影响。急性和慢性给予PCP均诱导了高运动活性、刻板行为和共济失调。给予PCP后，仅额叶皮质（Fc）中的NTLI显著降低。这些结果表明，Fc中NTLI的降低与PCP产生的行为异常有关。