Sturgeon R D, Fessler R G, Meltzer H Y
Eur J Pharmacol. 1979 Nov 16;59(3-4):169-79. doi: 10.1016/0014-2999(79)90279-6.
Behavioral rating scales were developed for quantification of phencyclidine (PCP)-induced locomotor activity, stereotyped behavior and ataxia in rats. The dose-response relationship for PCP-induced locomotor activity was found to be an inverted U-shaped function over the first 25 min after injection while over the last 30 min of the experiment the function was highly linear. A linear dose-response relationship was found for ratings of stereotyped behavior and ataxia throughout the 90 min period of observation. The ratings of these two behaviors were found to be closely parallel. The effects of PCP on locomotor activity were found to be greatest during those intervals when stereotyped behavior and ataxia were at moderate levels. Ratings of locomotor activity may be confounded by ataxia when PCP is administered alone or in combination with other drugs.
行为评分量表用于量化大鼠中苯环己哌啶（PCP）诱导的运动活动、刻板行为和共济失调。发现PCP诱导的运动活动的剂量反应关系在注射后的前25分钟内呈倒U形函数，而在实验的最后30分钟内该函数呈高度线性。在整个90分钟的观察期内，刻板行为和共济失调的评分呈线性剂量反应关系。发现这两种行为的评分密切平行。当刻板行为和共济失调处于中等水平时，发现PCP对运动活动的影响在这些时间段内最大。单独给予PCP或与其他药物联合使用时，运动活动评分可能会因共济失调而混淆。
