Yang Yongjin, Zhao Zhiyi, You Chengyu, Pang Miao, Zhong Tianyuan, Li Qingchao, Jing Shiwei, Qi Yanxin, Huang Yubin, Dong Zhilong
Department of Urology, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, 730000, Gansu, China.
Gansu Province Clinical Research Centre for Urinary System Disease, Lanzhou, 730000, Gansu, China.
J Mater Chem B. 2025 Jun 11;13(23):6701-6711. doi: 10.1039/d5tb00478k.
B agents are critical components in the application of boron neutron capture therapy (BNCT) for tumor treatment. The development of a multi-functional B agent plays an important role in the application of BNCT. This study presents a pioneering lyophilized-tumour-cell-based approach for the enhanced accumulation of B-doped carbon dots (B-CDs) within tumour tissue, irradiating thermal neutrons to treat prostate cancer. In this platform, lyophilized RM-1 cells function as both tumor cell antigens and delivery vehicles for B-CDs. This design facilitates the co-delivery of tumor antigens and B, thereby changing the immune status from "cold" to "hot" and prolonging the retention time of the B-CDs . Prostate cancer cells killed by BNCT mediated by this B agent not only damage the DNA, but ferroptosis is also an underlying mechanism. This powerful binary co-delivery system offers a novel strategy for combining BNCT with immunotherapy in the treatment of prostate cancer, providing a promising approach for BNCT-based combination immunotherapy.
硼剂是硼中子俘获疗法（BNCT）用于肿瘤治疗的关键组成部分。多功能硼剂的研发在BNCT的应用中起着重要作用。本研究提出了一种基于冻干肿瘤细胞的开创性方法，用于增强硼掺杂碳点（B-CDs）在肿瘤组织内的积累，通过照射热中子来治疗前列腺癌。在这个平台中，冻干的RM-1细胞既作为肿瘤细胞抗原，又作为B-CDs的递送载体。这种设计有助于肿瘤抗原和硼的共同递送，从而将免疫状态从“冷”转变为“热”，并延长B-CDs的保留时间。由这种硼剂介导的BNCT杀死的前列腺癌细胞不仅会损伤DNA，铁死亡也是一种潜在机制。这种强大的二元共同递送系统为BNCT与免疫疗法联合治疗前列腺癌提供了一种新策略，为基于BNCT的联合免疫疗法提供了一种有前景的方法。
