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用于前列腺癌诊断的量子点生物传感技术

Quantum Dot-Enabled Biosensing for Prostate Cancer Diagnostics.

作者信息

Omidian Hossein, Gill Erma J, Cubeddu Luigi X

机构信息

Barry and Judy Silverman College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL 33328, USA.

出版信息

Nanomaterials (Basel). 2025 Jul 28;15(15):1162. doi: 10.3390/nano15151162.

DOI:10.3390/nano15151162
PMID:40801702
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12348777/
Abstract

Prostate cancer diagnostics are rapidly advancing through innovations in nanotechnology, biosensing strategies, and molecular recognition. This review analyzes studies focusing on quantum dot (QD)-based biosensors for detecting prostate cancer biomarkers with high sensitivity and specificity. It covers diverse sensing platforms and signal transduction mechanisms, emphasizing the influence of the QD composition, surface functionalization, and bio interface engineering on analytical performance. Key metrics such as detection limits, dynamic range, and compatibility with biological samples, including serum, urine, and tissue, are critically assessed. Recent advances in green-synthesized QDs and smartphone-integrated diagnostic platforms are highlighted, including lateral flow assays, paper-based devices, and pH-responsive hydrogels for real-time, low-cost, and decentralized cancer screening. These innovations enable multiplexed biomarker detection and tumor microenvironment monitoring in point-of-care settings. This review concludes by addressing the current limitations, scalability challenges, and future research directions for translating QD-enabled biosensors into clinically viable diagnostic tools.

摘要

通过纳米技术、生物传感策略和分子识别方面的创新，前列腺癌诊断正在迅速发展。本综述分析了聚焦于基于量子点（QD）的生物传感器的研究，这些生物传感器用于高灵敏度和特异性地检测前列腺癌生物标志物。它涵盖了各种传感平台和信号转导机制，强调了量子点组成、表面功能化和生物界面工程对分析性能的影响。对诸如检测限、动态范围以及与包括血清、尿液和组织在内的生物样品的兼容性等关键指标进行了严格评估。突出了绿色合成量子点和集成智能手机的诊断平台的最新进展，包括侧向流动分析、纸质设备以及用于实时、低成本和分散式癌症筛查的pH响应水凝胶。这些创新使得在即时护理环境中能够进行多重生物标志物检测和肿瘤微环境监测。本综述最后讨论了将基于量子点的生物传感器转化为临床可行诊断工具的当前局限性、可扩展性挑战以及未来研究方向。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3de7/12348777/3044bb19c9d9/nanomaterials-15-01162-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3de7/12348777/246f08b7383b/nanomaterials-15-01162-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3de7/12348777/6437013b064b/nanomaterials-15-01162-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3de7/12348777/b3cda8518c1a/nanomaterials-15-01162-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3de7/12348777/c3612530b665/nanomaterials-15-01162-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3de7/12348777/3f6bb1a74806/nanomaterials-15-01162-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3de7/12348777/772686b15285/nanomaterials-15-01162-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3de7/12348777/5f8f98677eec/nanomaterials-15-01162-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3de7/12348777/9178c304263d/nanomaterials-15-01162-sch002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3de7/12348777/3044bb19c9d9/nanomaterials-15-01162-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3de7/12348777/246f08b7383b/nanomaterials-15-01162-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3de7/12348777/6437013b064b/nanomaterials-15-01162-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3de7/12348777/b3cda8518c1a/nanomaterials-15-01162-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3de7/12348777/c3612530b665/nanomaterials-15-01162-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3de7/12348777/3f6bb1a74806/nanomaterials-15-01162-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3de7/12348777/772686b15285/nanomaterials-15-01162-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3de7/12348777/5f8f98677eec/nanomaterials-15-01162-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3de7/12348777/9178c304263d/nanomaterials-15-01162-sch002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3de7/12348777/3044bb19c9d9/nanomaterials-15-01162-g007.jpg

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J Fluoresc. 2025 Jun 7. doi: 10.1007/s10895-025-04388-7.
2
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