Lopez-Ruiz Andrea A, Trinchet Lindsey P, Morozowich Steven, Misra Lopa
Alix School of Medicine, Mayo Clinic, Phoenix, AZ, USA.
Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Phoenix, AZ, USA.
Curr Pain Headache Rep. 2025 May 21;29(1):88. doi: 10.1007/s11916-025-01395-y.
Patients frequently report inadequate pain management following surgical procedures. Physicians must often prescribe analgesics, notably opioids, as a means of providing pain relief. Due to the addictive nature of this class of medications, improper post-surgical pain management propagates the United States opioid crisis. The administration of multimodal analgesia is a strategy implemented to decrease long-term outpatient prescription opioid use. Magnesium sulfate has recently attracted interest for its potential use as an adjunct in multimodal analgesia in addition to its other diverse uses in medicine. This review aims to highlight the most recent data validating the use of magnesium sulfate in perioperative multimodal analgesia.
A narrative review was conducted using PubMed and Ovid MEDLINE(R) Epub Ahead of Print, In-Process & Other Non-Indexed Citations. Articles that examined the effects of intravenous magnesium sulfate on perioperative pain and/or recovery from 1946 to present were considered. 15 articles met the inclusion criteria and discussed the use of magnesium sulfate as an adjunct in multimodal analgesia across the following surgical specialties: cardiac surgery, general surgery, gynecologic surgery, orthopedic surgery, urologic surgery, neurosurgery, and otolaryngology surgery. The results of the cited studies indicate that magnesium sulfate is a well-tolerated multimodal analgesic agent that reduces postoperative pain, reduces opioid consumption, and increases patient satisfaction.
患者经常报告手术后疼痛管理不足。医生通常必须开镇痛药，尤其是阿片类药物，作为缓解疼痛的一种手段。由于这类药物具有成瘾性，不当的术后疼痛管理加剧了美国的阿片类药物危机。多模式镇痛的给药是一种实施策略，旨在减少门诊患者长期使用处方阿片类药物的情况。硫酸镁最近因其在多模式镇痛中作为辅助药物的潜在用途以及在医学中的其他多种用途而受到关注。本综述旨在强调验证硫酸镁在围手术期多模式镇痛中应用的最新数据。
使用PubMed和Ovid MEDLINE(R) Epub Ahead of Print、In-Process & Other Non-Indexed Citations进行了叙述性综述。考虑了1946年至今研究静脉注射硫酸镁对围手术期疼痛和/或恢复影响的文章。15篇文章符合纳入标准，并讨论了硫酸镁在以下外科专业中作为多模式镇痛辅助药物的应用：心脏外科、普通外科、妇科手术、骨科手术、泌尿外科手术、神经外科手术和耳鼻喉科手术。引用研究的结果表明，硫酸镁是一种耐受性良好的多模式镇痛剂，可减轻术后疼痛、减少阿片类药物消耗并提高患者满意度。
