Chuck L H, Refsum H, Rouleau J L, Mathey D, Sievers R E, Parmley W W
Am Heart J. 1984 Jul;108(1):97-104. doi: 10.1016/0002-8703(84)90550-7.
We studied 56 right ventricular papillary muscles isolated from cats to determine whether the direct mechanical effects of contrast media are due to their pharmacologic action or to the hyperosmolality caused by them. A 10% solution of Renografin-76 abruptly decreased force 22% below control, then slowly increased it to 22% above control. To elucidate these changes we also studied: (1) Renografin-60 (lower concentration of diatrizoate); (2) meglumine and diatrizoate; (3) meglumine alone; (4) diatrizoate sodium; (5) ethylene diamine tetra-acetic acid (EDTA) (same concentration as in Renografin-76); (6) sucrose to increase osmolality; and (7) Amipaque (metrizamide), a contrast medium without meglumine or diatrizoate. All solutions containing meglumine, and EDTA alone decreased force. Diatrizoate sodium also decreased force initially, presumably due to the high sodium concentration. Meglumine alone decreased force abruptly and substantially. In contrast, metrizamide and 100 mmol sucrose only increased force. Thus, the abrupt decrease in force was caused by the pharmacologic action of meglumine, EDTA, or high sodium in the contrast media, whereas the slow increase in force was caused by hyperosmolality.
我们研究了从猫身上分离出的56块右心室乳头肌，以确定造影剂的直接机械作用是由于其药理作用还是由其引起的高渗性。10%的泛影葡胺-76溶液使力量突然降至比对照低22%，然后又缓慢升至比对照高22%。为了阐明这些变化，我们还研究了：（1）泛影葡胺-60（较低浓度的泛影酸盐）；（2）葡甲胺和泛影酸盐；（3）单独的葡甲胺；（4）泛影酸钠；（5）乙二胺四乙酸（EDTA）（与泛影葡胺-76中的浓度相同）；（6）蔗糖以增加渗透压；（7）阿米培克（甲泛葡胺），一种不含葡甲胺或泛影酸盐的造影剂。所有含葡甲胺的溶液以及单独的EDTA都会使力量降低。泛影酸钠最初也会使力量降低，可能是由于高钠浓度。单独的葡甲胺会使力量突然大幅降低。相比之下，甲泛葡胺和100 mmol蔗糖只会使力量增加。因此，力量的突然降低是由造影剂中葡甲胺、EDTA或高钠的药理作用引起 的，而力量的缓慢增加是由高渗性引起的。
