Toda T, Toda Y, Kummerow F A
Tohoku J Exp Med. 1985 Mar;145(3):303-10. doi: 10.1620/tjem.145.303.
Ultrastructural studies were conducted on the coronary arteries of 6 week-old piglets from sows which received diets containing either 25 micrograms or 3.7 micrograms of vitamin D3 per pound of basal ration. The subendothelial space which was rich in mucopolysaccharide and newly formed tiny elastic fibers, contained numerous macrophages, some of which possessed lipid droplets. Degenerated smooth muscle cells with pyknotic nuclei or vesiculated organelles, and mitotic smooth muscle cells were occasionally seen in the coronary artery. Piglets from sows which were fed high doses of vitamin D had more degenerated smooth muscle cells without stainable lipid and lipid containing cells in their coronary arteries than piglets from sows which were fed low doses of vitamin D. These results suggested that an excess dietary intake of vitamin D by pregnant animals may have potential angiotoxic effects on the coronary arteries of their offsprings.
对6周龄仔猪的冠状动脉进行了超微结构研究，这些仔猪来自于喂食每磅基础日粮含25微克或3.7微克维生素D3日粮的母猪。富含粘多糖和新形成的微小弹性纤维的内皮下间隙含有大量巨噬细胞，其中一些巨噬细胞含有脂滴。在冠状动脉中偶尔可见核固缩或细胞器空泡化的变性平滑肌细胞以及有丝分裂的平滑肌细胞。与喂食低剂量维生素D的母猪所产仔猪相比，喂食高剂量维生素D的母猪所产仔猪的冠状动脉中有更多不含可染色脂质的变性平滑肌细胞和含脂质细胞。这些结果表明，怀孕动物饮食中维生素D摄入过量可能对其后代的冠状动脉具有潜在的血管毒性作用。
