Wang Ling, Huang Qingmei, Cai Tingting, Ding Yuanqi, Yuan Changrong
School of Nurisng, Fudan University, Shanghai, China.
School of Nurisng, Fudan University, Shanghai, China
BMJ Open. 2025 May 21;15(5):e098064. doi: 10.1136/bmjopen-2024-098064.
Exercise is the main treatment for patients with breast cancer-related lymphedema (BCRL) and different types of exercises were performed in these patients. However, it is unclear which type of exercise or combination of these is the most effective in reducing arm swelling and lymphedema-related symptoms, and quality of life in patients with BCRL.
This study aimed to compare the relative efficacy of different types of exercise in treating BCRL and determine the most effective exercise therapy for patients with BCRL.
This review will search English-language databases (Cochran Library, Cumulative Index to Nursing and Allied Health Literature, EBSCO, EMBASE, PubMed/Medline and Web of Science). The following Chinese-language databases will also be searched: Chinese Biomedical Literature Database (SinoMed), China National Knowledge Infrastructure, Wanfang Data and China Science and Technology Journal Database. The search was conducted up to 31 December 2024. Randomised controlled trials comparing different types of exercise on BCRL will be eligible. Data will be extracted from eligible trials by two independent researchers based on the selection criteria. Two reviewers will ascertain the risk of bias of the selected studies using a modified version of the Cochrane Risk of Bias Tool. The study's characteristics (study type, characteristics of the patients, intervention prescriptions) and primary outcomes (limb volume, physical function, physical and psychological symptoms) will be summarised in a narrative format. Meta-analyses (ie, network and pairwise) will be used to assess the indirect and direct effects of the exercise interventions. The relative effects of different types of exercise in treating BCRL will be examined by the surface under the cumulative ranking curve to calculate the ranking of treatments and determine the most effective intervention.
This review does not require ethical approval. The findings will be submitted for peer-reviewed publication.
The systematic review protocol has been registered in the International Prospective Register for Systematic Reviews (CRD42022370817).
运动是乳腺癌相关淋巴水肿（BCRL）患者的主要治疗方法，这些患者进行了不同类型的运动。然而，尚不清楚哪种类型的运动或这些运动的组合在减轻手臂肿胀、淋巴水肿相关症状以及BCRL患者的生活质量方面最有效。
本研究旨在比较不同类型运动治疗BCRL的相对疗效，并确定BCRL患者最有效的运动疗法。
本综述将检索英文数据库（Cochrane图书馆、护理及相关健康文献累积索引、EBSCO、EMBASE、PubMed/Medline和科学引文索引）。还将检索以下中文数据库：中国生物医学文献数据库（SinoMed）、中国知网、万方数据和中国科技期刊数据库。检索截至2024年12月31日。比较不同类型运动对BCRL影响的随机对照试验将符合纳入标准。两名独立研究人员将根据选择标准从符合条件的试验中提取数据。两名评审员将使用Cochrane偏倚风险工具的修改版确定所选研究的偏倚风险。将以叙述形式总结研究特征（研究类型、患者特征、干预方案）和主要结局（肢体体积、身体功能、身体和心理症状）。将使用荟萃分析（即网状和成对分析）评估运动干预的间接和直接效果。通过累积排名曲线下的面积来检查不同类型运动治疗BCRL的相对效果，以计算治疗排名并确定最有效的干预措施。
本综述无需伦理批准。研究结果将提交同行评审发表。
PROSPERO注册号：该系统评价方案已在国际前瞻性系统评价注册库（CRD42022370817）注册。
