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Recovery from deep neuromuscular blockade using different sugammadex doses in elderly patients undergoing laparoscopic robot-assisted prostatectomy: A prospective, randomised, double-blind, phase III trial.

作者信息

Aceto Paola, Russo Andrea, Cambise Chiara, Luca Ersilia, Schipa Chiara, Fortunato Giusy, Romanò Bruno, Sacco Emilio, Totaro Angelo, Campetella Marco, Federico Bruno, Dello Russo Cinzia, Sollazzi Liliana

机构信息

From the Department of Basic Biotechnological Science, Intensive and Peri-operative Clinics, Università Cattolica del Sacro Cuore (PA, LS), Department of Emergency, Anaesthesiologic and Reanimation Sciences, Fondazione Policlinico Universitario Agostino Gemelli IRCCS (PA, AR, CC, EL, CS, GF, BR, LS), Institute of Urology, Università Cattolica del Sacro Cuore-Fondazione Policlinico A. Gemelli (ES, AT), Department of Urology, Ospedale Isola Tiberina - Gemelli Isola (ES), Department of Urology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome (AT, MC), Department of Human Sciences, Society and Health, University of Cassino and Southern Lazio, Cassino (BF), Department of Healthcare Surveillance and Bioethics, Section of Pharmacology, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy (CDR), Department of Pharmacology & Therapeutics, Institute of Systems Molecular and Integrative Biology (ISMIB), University of Liverpool, Liverpool, UK (CDR).

出版信息

Eur J Anaesthesiol. 2025 Aug 1;42(8):747-750. doi: 10.1097/EJA.0000000000002206. Epub 2025 May 21.

DOI:10.1097/EJA.0000000000002206
PMID:40400264
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12237094/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91fb/12237094/b3b50e699a41/ejanet-42-747-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91fb/12237094/52050098c066/ejanet-42-747-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91fb/12237094/b3b50e699a41/ejanet-42-747-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91fb/12237094/52050098c066/ejanet-42-747-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91fb/12237094/b3b50e699a41/ejanet-42-747-g002.jpg

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Challenges for anaesthesia for robotic-assisted surgery in the elderly: A narrative review.老年患者机器人辅助手术的麻醉挑战：一篇叙述性综述。
Eur J Anaesthesiol Intensive Care. 2023 Feb 9;2(2):e0019. doi: 10.1097/EA9.0000000000000019. eCollection 2023 Apr.
2
A Dose-finding Study of Sugammadex for Reversal of Rocuronium in Cardiac Surgery Patients and Postoperative Monitoring for Recurrent Paralysis.罗库溴铵拮抗的剂量探索：一项心脏手术患者和术后复发性神经肌肉阻滞监测的研究
Anesthesiology. 2023 Jul 1;139(1):6-15. doi: 10.1097/ALN.0000000000004578.
3
Peri-operative management of neuromuscular blockade: A guideline from the European Society of Anaesthesiology and Intensive Care.
神经肌肉阻滞的围手术期管理：欧洲麻醉学与重症监护学会指南
Eur J Anaesthesiol. 2023 Feb 1;40(2):82-94. doi: 10.1097/EJA.0000000000001769. Epub 2022 Nov 15.
4
Sugammadex compared with neostigmine in reducing postoperative pulmonary complications in older patients: a meta-analysis.舒更葡糖钠与新斯的明相比对老年患者术后肺部并发症的影响：一项荟萃分析
Br J Anaesth. 2022 Apr;128(4):e259-e262. doi: 10.1016/j.bja.2021.12.038. Epub 2022 Jan 25.
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First genome-wide association study on rocuronium dose requirements shows association with SLCO1A2.首个罗库溴铵剂量需求的全基因组关联研究显示与 SLCO1A2 相关。
Br J Anaesth. 2021 May;126(5):949-957. doi: 10.1016/j.bja.2021.01.029. Epub 2021 Mar 4.
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Joint consensus on anesthesia in urologic and gynecologic robotic surgery: specific issues in management from a task force of the SIAARTI, SIGO, and SIU.《泌尿外科和妇科机器人手术中的麻醉共识：来自 SIAARTI、SIGO 和 SIU 的工作组在管理方面的具体问题》。
Minerva Anestesiol. 2019 Aug;85(8):871-885. doi: 10.23736/S0375-9393.19.13360-3. Epub 2019 Mar 29.
7
Elderly Patients Require Higher Doses of Sugammadex for Rapid Recovery from Deep Neuromuscular Block.老年患者需要更高剂量的舒更葡糖钠才能从深度神经肌肉阻滞中快速恢复。
Basic Clin Pharmacol Toxicol. 2016 Jun;118(6):462-7. doi: 10.1111/bcpt.12507. Epub 2015 Nov 27.
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Acta Anaesthesiol Scand. 2015 Aug;59(7):892-901. doi: 10.1111/aas.12549. Epub 2015 May 12.
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Br J Anaesth. 2011 Jun;106(6):823-6. doi: 10.1093/bja/aer098. Epub 2011 Apr 29.
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Acceleromyography for use in scientific and clinical practice: a systematic review of the evidence.用于科学和临床实践的加速度肌动描记术：证据的系统评价
Anesthesiology. 2008 Jun;108(6):1117-40. doi: 10.1097/ALN.0b013e318173f62f.