Squire R A
Food Chem Toxicol. 1985 Apr-May;23(4-5):491-7. doi: 10.1016/0278-6915(85)90143-7.
Bladder tissues from rats treated with sodium saccharin in a two-generation dose-response study, in which 1.0% in the diet had been identified as the no-effect level for primary bladder cancer, were re-examined without knowledge of the test groups or the previous histopathological findings. Compound-related increases in the incidences of hyperplasia were found at the 6.25 and 7.5% saccharin levels (the highest dietary levels tested). There were also compound-related increased in the incidence of transitional-cell papillomas and/or carcinomas at the 4.0, 5.0, 6.25 and 7.5% levels. There was a slight increase in the incidence of transitional-cell carcinomas at the 3.0% level, but this was not statistically significant (P = 0.25). No compound-related effects were evident at the 1.0% level. All tumours were well to moderately differentiated and there was no increase in mean grades of severity or anaplasia for any proliferative lesion.
在一项两代剂量反应研究中，用糖精钠处理大鼠后获取膀胱组织，在该研究中，饮食中1.0%的糖精被确定为原发性膀胱癌的无效应水平，在不了解测试组或先前组织病理学结果的情况下对这些组织进行了重新检查。在糖精水平为6.25%和7.5%（测试的最高饮食水平）时，发现与化合物相关的增生发生率增加。在4.0%、5.0%、6.25%和7.5%的水平时，与化合物相关的移行细胞乳头状瘤和/或癌的发生率也增加。在3.0%的水平时，移行细胞癌的发生率略有增加，但这在统计学上不显著（P = 0.25）。在1.0%的水平时，未发现与化合物相关的影响。所有肿瘤均为高分化至中分化，任何增生性病变的严重程度或间变平均分级均未增加。
