Kulkarni P S, Ambani L M, Bhandarkar S D
Food Chem Toxicol. 1985 Jun;23(6):625-8. doi: 10.1016/0278-6915(85)90190-5.
Chromosome studies were carried out on the peripheral blood of nine diabetic patients treated with chlorpropamide, on nine healthy controls and on nine untreated diabetic controls. Data from each treated individual were compared with the mean of the pooled data from the two control groups. There was a statistically significant increase in the individual numbers of sister chromatid exchanges per metaphase in each of the patients treated with the drug compared with the mean of the pooled control values. There was no significant increase in the numbers of structural chromosomal aberrations in the treated patients compared with the controls.
对9名接受氯磺丙脲治疗的糖尿病患者、9名健康对照者和9名未经治疗的糖尿病对照者的外周血进行了染色体研究。将每位接受治疗患者的数据与两个对照组汇总数据的均值进行比较。与对照组汇总值的均值相比，接受该药物治疗的每位患者中期姊妹染色单体交换的个体数量有统计学意义的增加。与对照组相比，接受治疗患者的结构染色体畸变数量没有显著增加。
